Comprehensive Psychiatry, 2020 Background: In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms. Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects.
Xi-juan Sun +3 more
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MK-801 is a potent nematocidal agent. Characterization of MK-801 binding sites in Caenorhabditis elegans [PDF]
Biochemical Journal, 1989 MK-801, an N-methyl-D-aspartate antagonist in mammalian brain tissue, is a potent nematocidal agent. Specific MK-801 binding sites have been identified and characterized in a membrane fraction prepared from the free-living nematode Caenorhabditis elegans. The high-affinity MK-801 binding site has an apparent dissociation constant, Kd, of 225 nM. Unlike
J M, Schaeffer +2 more
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Convergent Strategy to Dizocilpine MK-801 and Derivatives [PDF]
The Journal of Organic Chemistry, 2018 A convergent total synthesis of MK-801 has been achieved. Key synthetic transformations include a multicomponent Barbier-type reaction to construct the α-branched amine, a selective Heck α-coupling tactic to generate the exocyclic alkene skeleton, and a late-stage intramolecular hydroamination reaction between the exocyclic alkene and the secondary ...
Vardhan Reddy, K. Harsha +4 more
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Phencyclidine and (+)-MK-801-induced circling preference: correlation with monoamine levels in striatum of the rat brain [PDF]
, 1994 Phencyclidine (PCP; angel dust) is a drug of abuse known to produce a behavioral state in humans resembling schizophrenia/psychosis. PCP is a noncompetitive NMDA receptor antagonist and produces a variety of behaviors in rats including circling.
Ali, SF, Bracha, HS, Newport, GD
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Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat [PDF]
, 2007 The administration of noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine and ketamine has been shown to increase the extracellular concentration of glutamate and serotonin (5-HT) in the medial prefrontal cortex (mPFC ...
López-Gil, Xavier +5 more
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Neurobiology of Disease, 2007 The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801.
Colin Kehrer +6 more
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Dose-dependent and combined effects of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine on the survival of retinal ganglion cells in adult hamsters [PDF]
, 2012 This study investigated the effects of daily intraperitoneal injections of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine (L-NA) on the survival of retinal ganglion cells (RGCs) at 1 and 2 weeks after
Li, Y +5 more
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Cannabidiol Attenuates Sensorimotor Gating Disruption and Molecular Changes Induced by Chronic Antagonism of NMDA receptors in Mice [PDF]
, 2015 Background: Preclinical and clinical data suggest that cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa, induces antipsychotic-like effects.
Del Bel, Elaine A. +5 more
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Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine [PDF]
, 2016 Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our previous study indicates that MK-801 (dizocilpine), NMDA antagonist, increased anxiety and prevented the ...
Abuhamdah, R.M. +3 more
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MK‐801 blocks monoamine transporters expressed in HEK cells [PDF]
FEBS Letters, 1998 (+)‐MK‐801 is known to be a specific non‐competitive antagonist of N‐methyl‐d‐aspartate (NMDA) receptors. However, besides having an anticonvulsant effect, this compound possesses a central sympathomimetic effect and an anxiolytic‐like action, raising the possibility that (+)‐MK‐801 might affect monoamine uptake systems.
Nishimura, Mitsuhiro +5 more
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