Results 191 to 200 of about 15,502 (223)

PANoptosis and mitochondrial regulatory mechanisms in cerebral ischemia-reperfusion injury. [PDF]

Front Physiol
Li L, Guo C, Zuo Z, Cai L, Chen X, Fang Y, Zhang S, Chen T, Kuang P, Zhang P, Li L, Wang Z.   +11 more
europepmc   +1 more source

MLKL forms cation channels [PDF]

Cell Research, 2016
The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited.
Xia, Bingqing, Fang, Sui, Chen, Xueqin, Hu, Hong, Chen, Peiyuan, Wang, Huayi, Gao, Zhaobing   +6 more
exaly   +8 more sources

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis [PDF]

Cell Research, 2013
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines. We have generated Mlkl-deficient mice by transcription activator-like effector nucleases (TALENs)-mediated gene ...
Zhe Huang, Zhirong Zhang, Wanze Chen
exaly   +4 more sources

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PROTACs Targeting MLKL Protect Cells from Necroptosis

Journal of Medicinal Chemistry, 2023
Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as an attractive drug target. Here, we describe the development of PROteolysis TArgeting Chimeras (PROTACs) as a novel approach to knock down MLKL through chemical means.
Oliver H. Rathje, Lara Perryman, Richard J. Payne, Dieter W. Hamprecht   +3 more
openaire   +2 more sources

Necrosome core machinery: MLKL

Cellular and Molecular Life Sciences, 2016
In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in particular necroptosis, has been drawing much attention. The signaling of necroptosis represents a sophisticated form of a death pathway. Anti-caspase mechanisms (e.g., using inhibitors of caspases, or genetic ablation of caspase-8) switch cell fate from ...
Jing, Zhang, Yu, Yang, Wenyan, He, Liming, Sun   +3 more
openaire   +2 more sources

MLKL in cancer: more than a necroptosis regulator

Cell Death & Differentiation, 2021
Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of cancer. Besides apoptosis, some cancers suppress necroptosis-associated mechanisms by for example epigenetic silencing of RIPK3 expression.
Sofie Martens, Jolien Bridelance, Ria Roelandt, Peter Vandenabeele, Nozomi Takahashi   +4 more
openaire   +2 more sources

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis [PDF]

Molecular Cell, 2018
Necroptosis is an important form of lytic cell death triggered by injury and infection, but whether mixed lineage kinase domain-like (MLKL) is sufficient to execute this pathway is unknown. In a genetic selection for human cell mutants defective for MLKL-dependent necroptosis, we identified mutations in IPMK and ITPK1, which encode inositol phosphate ...
Bradley P Clarke, Andrew T Hale, Dan E Mcnamara   +2 more
exaly   +3 more sources

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL [PDF]

Molecular Cell, 2019
Necroptosis, a cell death pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade downstream of tumor necrosis factor α (TNF-α), has been implicated in many inflammatory diseases. Members of the TAM (Tyro3, Axl, and Mer) family of receptor tyrosine kinases are known for their anti-apoptotic, oncogenic, and anti-inflammatory roles.
Ayaz Najafov, Adnan K Mookhtiar, Alban Ordureau   +2 more
exaly   +3 more sources

TAMs target MLKL

Science Signaling, 2019
TAM family kinases promote necroptosis by stimulating the phosphorylation and oligomerization of the pseudokinase MLKL.
openaire   +1 more source