Results 201 to 210 of about 13,017 (220)
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Necroptosis: MLKL Polymerization.
Journal of nature and scienceNecroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers caspase independent, immunogenic cell death. The core pathway relies on receptor interacting protein kinase (RIPK) 1 and 3, which interact through their receptor ...
Andrea, Johnston, Zhigao, Wang
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Advances in MLKL-targeted inhibitors and PROTACs for necroptosis therapeutics
Bioorganic & Medicinal ChemistryNecroptosis is a highly regulated form of cell death. Mixed lineage kinase domain-like protein (MLKL) serves as its central effector and plays a critical role in various physiological and pathological processes. Given its close association with multiple diseases, MLKL has emerged as a promising therapeutic target. This review highlights recent advances
Pengcheng, Dai +4 more
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The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
Journal of Molecular Cell Biology, 2021Yang Wang, An Tong, Qiangsheng Zhang
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RIPK3–MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis
Clinical and Translational Medicine, 2023Jianan Ren
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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Cell, 2017Andreas Linkermann +2 more
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2015
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The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process
Molecular and Cellular Biology, 2017Jiahuai Han +2 more
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
Proceedings of the National Academy of Sciences of the United States of America, 2017Kaiwen W Chen +2 more
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