Results 251 to 260 of about 390,769 (349)

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Hypotonicity-Induced WNK1 Phosphorylation Prevents H₂O₂-Induced Apoptosis in Vascular Smooth Muscle Cells. [PDF]

Basic Clin Pharmacol Toxicol
Zhang Y, Lin W, Lu F, Liang Z, Huang C, Mingming M, Sijia L, Ruiping P, Zhou J, Guan Y, Liang G, Lv X.   +11 more
europepmc   +1 more source

MT1‐MMP: A potent modifier of pericellular microenvironment

Journal of Cellular Physiology, 2006
Y. Itoh, M. Seiki
semanticscholar   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Pathological characteristics of cervical lymph node metastases in papillary thyroid carcinoma compared with lung adenocarcinoma. [PDF]

Front Oncol
Shao MX, Niu Y, Wei Y, Zhao ZL, Yu MA.
europepmc   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

CHL Attenuates MIA-Induced Osteoarthritis by Regulating Inflammatory, Catabolic, and Anabolic Pathways Associated with Cartilage and Subchondral Bone Degeneration. [PDF]

Nutrients
Sanjay, Woo MS, Yoo J, Pfannenschmidt T, Lee HJ.   +4 more
europepmc   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Circulating Extracellular Matrix-Remodeling Biomarkers in Children with Bicuspid Aortic Valve: An Exploratory Cross-Sectional Study. [PDF]

Diagnostics (Basel)
Man OI, Mureșan XM, Nistor M, Negru A, Tarcău BM, Agoston R, Orzan RI, Șufană C, Lazăr C, Agoston-Coldea L, Lazea C.   +10 more
europepmc   +1 more source