Results 261 to 270 of about 390,769 (349)

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study. [PDF]

J Clin Med
Gromadzki B, Wiciński M, Siedlecki Z, Porzych R, Pisarski I.   +4 more
europepmc   +1 more source

MMP [PDF]

, 2019
openaire   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Diosgenin enhances transplanted human oligodendrocyte precursor cell-mediated myelination in preterm white matter injury by inhibiting matrix metalloproteinase-9-driven TGF-β/Smad2/3 signaling. [PDF]

Neurotherapeutics
Lai Q, Yao X, Bai L, Cao X, Zhao Y, Wang C, Luan Z, Feng Z, Yao R.   +8 more
europepmc   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Association Between Serum Matrix Metalloproteinase-3 Levels and Cognitive Function in Patients With Rheumatoid Arthritis. [PDF]

Int J Rheum Dis
Xu L.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Green-Synthesized Silver Nanoparticles from <i>Filipendula ulmaria</i> and <i>Salvia verticillata</i> Extracts Exert Antimetastatic and Anti-Inflammatory Effects Through Redox-Mediated Nrf-2/NF-κB/MMP-2/9 Signaling in Human Colon Cancer Cells. [PDF]

Antioxidants (Basel)
Matić M, Paunović M, Ognjanović B, Srećković N, Mihailović N, Mihailović V, Obradović A.   +6 more
europepmc   +1 more source