Results 281 to 290 of about 390,769 (349)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +1 more source

Associations of tear mediators with ocular surface symptoms, signs, and corneal nerve morphology in dry eye disease: a cross-sectional study. [PDF]

Front Med (Lausanne)
Cui L, Jia R, Yu C, Xu Z, Yao Y, Guo J, Ren X.   +6 more
europepmc   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +1 more source

Changes in dermoscopic photoaging and serum MMP-1 following 12 weeks of 5% lady finger banana peel extract nanoparticle serum: a single-arm proof-of-concept study. [PDF]

Front Med (Lausanne)
Nasution K, Jusuf NK, Putra IB, Harahap J, Djawad K, Alferraly I, Amin MM, Sukatendel K.   +7 more
europepmc   +1 more source

Routine Inflammation-Haemostasis Panel in Transvenous Lead Extraction: An Exploratory Prospective Single-Centre Cohort Study. [PDF]

J Clin Med
Rokicki JK, Wolff S, Januszkiewicz Ł, Michalak M, Czarzasta K, Cacko A, Opolski G, Grabowski M.   +7 more
europepmc   +1 more source

Application value of blood-brain barrier and peripheral inflammatory markers in early diagnosis of pancreatic encephalopathy in severe acute pancreatitis. [PDF]

Front Neurosci
Xu L, Liu C, Zhu G.
europepmc   +1 more source

MMP-2 Responsive Functional Bladder Acellular Matrix Scaffold Combined With Urine Derived Stem Cells for Bladder Nerve Regeneration. [PDF]

Chembiochem
Xia H, Wang X, Chen W.
europepmc   +1 more source

Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood-brain barrier disruption in dementia. [PDF]

Front Aging
Golduzian A, Erhardt EB, Caprihan A, Adair JC, Knoefel JE, Prestopnik J, Hobson S, Ryman S, Vakhtin A, Bhaskar K, Rosenberg GA.   +10 more
europepmc   +1 more source