Results 271 to 280 of about 390,769 (349)

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Microenvironment of Sarcomas Associated and Not Associated with Inoculation Sites in Domestic Cats: The Role of Metalloproteinases and Angiogenic Factors. [PDF]

Biology (Basel)
Wright C, Scarano AC, Verdes JM, Scenna SG, Duchene AG, Osacar JM, Di Pierro LM, Risso P, Badura E, Barbeito CG, Acuña F, Santelices Iglesias OA.   +11 more
europepmc   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Targeting oxidative stress-MMP-2 signaling in hypertension-induced cardiovascular remodeling and dysfunction. [PDF]

Front Pharmacol
Blascke de Mello MM, Pernomian L, Ramos LVR, Castro MM.   +3 more
europepmc   +1 more source

Methacrylated Gelatin and Graphene Oxide Hybrid Hydrogels Composed‐Bioinks for 3D Tissue Engineering

Advanced NanoBiomed Research, EarlyView.
Bioinks made from hydrogels, such as methacrylated gelatin (GelMA), serve as the base material for bioprinted tissues, offering versatility and biocompatibility for a range of applications. Additional components however are still needed to improve functionality and mechanical stability of hydrogels. One of these components is graphene oxide (GO), added
Wanessa S. Mota, Erika S. Lisboa, Victoria L. S. dos Santos, Carine Serafim, Maria L. F. Bezerra, Thais F. R. Alves, Marco V. Chaud, Frederico S. Martins, Juliana C. Cardoso, Eliana B. Souto, Patrícia Severino   +10 more
wiley   +1 more source

Magnocurarine inhibits migration and invasion by suppressing mesenchymal marker expression and MAPK signaling in castration-resistant prostate cancer cells. [PDF]

Front Pharmacol
Semmarath W, Arjsri P, Srisawad K, Thippraphan P, Intanil I, Umsumarng S, Dejkriengkraikul P.   +6 more
europepmc   +1 more source

A Comprehensive In Vitro Approach for Assessing the Physiological Degradation of Medical Implants: The Silkothane Arteriovenous Graft Case Study

Advanced NanoBiomed Research, EarlyView.
Evaluating the degradation of absorbable medical devices in vitro demands physiologically relevant conditions. This study presents a comprehensive framework applied to a three‐layered silk fibroin/polyurethane arteriovenous graft, employing human enzymes at physiological concentrations over 6 months. Multiparametric analyses of both graft structure and
Cristina Oldani, Alice Caldiroli, Federica Barzaghi, Nina Bono, Gabriele Candiani, Stefania Adele Riboldi   +5 more
wiley   +1 more source

Ferulic Acid Modulates High Glucose-Induced MMP-1/TIMP-1 Imbalance and Enhances Wound Closure of Human Gingival Fibroblasts. [PDF]

Biomedicines
Özdemir A, Yüncü A, Yılmaz AM, Öztürk Özener H.   +3 more
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Matrix Metalloproteinases and Cardiac Remodelling in Smokers with Acute Coronary Syndrome. [PDF]

Int J Mol Sci
Aminuddin A, Samah N, Nor FM, Wan Razali WMH, Cong BB, Mohamad SF, Hamid AA, Norhisham WK, Ugusman A.   +8 more
europepmc   +1 more source