Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Experimental Study on the Effect of Human-in-the-loop Integration on Large Language Model-based Process Control in Additive Manufacturing [PDF]
한국정밀공학회지This study proposes a human-in-the-loop framework that integrates operator observations into a large language model (LLM) to control process parameters for defect handling in fused deposition modeling (FDM) 3D printing. Fully autonomous LLM-based control
Seongyoon Jeon, Taehwan Kim, Namhun Kim
doaj +1 more source
An integrated System Dynamics model for Closed Loop Supply Chains under disaster effects: The case of COVID-19. [PDF]
Int J Prod Econ, 2022 Katsoras E, Georgiadis P.
europepmc +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Blood-brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication. [PDF]
Sci Rep, 2022 Chien CY, Xu L, Pacia CP, Yue Y, Chen H.
europepmc +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Modeling and Control of a Road Wheel Actuation Module in Steer-by-Wire System
ActuatorsSince the steer-by-wire system removes the mechanical connection and uses electrical signals to drive the system, it has the disadvantage of being less stable in the failure of parts or systems.
Insu Chung, Jungdai Choi, Kanghyun Nam
doaj +1 more source