Results 101 to 110 of about 739,145 (318)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investment in Tourism Market: A Dynamic Model of Differentiated Oligopoly [PDF]
We present a theoretical model in tourism economics, assuming that the market for tourism is an oligopoly with differentiated products. Destinations (i.e., countries, regions, sites or even firms) can invest in order to improve their carrying capacity ...
Guido Candela, Roberto Cellini
core
A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells [PDF]
, 2014 Neurogenesis is initiated by a set of basic Helix-Loop-Helix (bHLH) transcription factors that specify neural progenitors and allow them to generate neurons in multiple rounds of asymmetric cell division.
Heinrich Reichert +15 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Hardware-in-the-loop Multi-satellite Simulator for Proximity Operations
, 2010 This paper addresses the first steps realized to set up a hardware in-the-loop (HWIL) multi-satellite simulator aimed at the support of closed-loop real-time real-scale On-Orbit Servicing (OOS) scenarios.
Ardeans Jean-Sébastien +7 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dynamic pricing model for the operation of closed-loop supply chain system
, 2011 A class of closed-loop supply chain system consisting of one manufacturer and one supplier is designed, in which re-distribution, remanufacturing and reuse are considered synthetically.
Zhu YL(朱云龙) +3 more
core
From state-of-the-art ventilation to closed loop ventilation
, 2022 Recent emphasis on energy load delivered during each ventilatory breath has opened a new insight to reduce harmful ventilatory induced lung injury, but no robust clinical evidence of patient benefit produced yet. Closed loop ventilation is a strategy to
Andreas Schibler +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
NONRENEWABLE RESOURCE OLIGOPOLIES AND THE CARTEL-FRINGE GAME [PDF]
We specify and solve a closed-loop dominant firm nonrenewable resource game, with a price-taking fringe. We show that (i) the outcomes of the closed-loop and the open-loop dominant firm nonrenewable resource game (a la Salant 1976) coincide and (ii) when
Cees Withagen, Hassan Benchekroun
core