Results 61 to 70 of about 270,769 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of short-term pre-aging in vacuum on physicochemical characteristics and consumer acceptability of modified atmosphere packed beef steaks

Irish Journal of Agricultural and Food Research, 2015
The objective of this study was to investigate the physiochemical changes and consumer acceptability of meat packed in high oxygen modified atmosphere during 12 days of storage with and without pre-aging in vacuum for 7 days.
Łopacka Joanna, Żontała Katarzyna, Pietras Jacek, Półtorak Andrzej, Wierzbicka Agnieszka   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Estudo de cobertura comestível com propriedades antifúngicas e atmosfera modificada na manutenção da qualidade de tomate cereja (Lycopersicon esculentum var. Cerasiforme) [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2013.O tomate é uma hortaliça de grande produção e consumo no Brasil.
Fagundes, Cristiane
core  

Gas Atmosphere Innovation Applied to Prolong the Shelf Life of ‘Regina’ Sweet Cherries

Plants
In this study, the impact of moderate and high CO2 and O2 levels was compared to low and moderate gas combinations during prolonged storage on the quality of Regina sweet cherries harvested in different maturity stages, particularly in terms of ...
Rodrigo Neira-Ojeda, Sebastián Rodriguez, Cristian Hernández-Adasme, Violeta Muñoz, Dakary Delgadillo, Bo Sun, Xiao Yang, Victor Hugo Escalona   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Pré-solubilização de CO2 em ostras (Crassostrea gigas): avaliação do processo de absorção e dessorção do gás no produto [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2013.O efeito da pré-solubilização de CO2 tem sido estudado como melhoria dos processos com ...
Soares, Lenilton Santos
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Physicochemical Changes and Antioxidant Metabolism of Actinidia arguta Fruit (Kiwiberry) Under Various Cold-Storage Conditions

Molecules
Actinidia arguta (kiwiberry) is a fruit with significant health benefits, and research continues to identify factors that enhance its storability while maintaining quality.
Barbara Łata, Rafał Wołosiak, Ewa Majewska, Beata Drużyńska, Małgorzata Piecyk, Katarzyna Najman, Anna Sadowska, Piotr Latocha   +7 more
doaj   +1 more source

Quality of beans stored under hermetic conditions Qualidade de feijão armazenado em condições herméticas

Engenharia Agrícola, 2011
This study aimed to evaluate the quality of beans (Phaseolus vulgaris L.) stored with different moisture contents under hermetic conditions. Beans with 12.3%, 15.7%, and 17.8% moisture content were used in the experiment.
Romenique da S Freitas, Lêda R. DA Faroni, Adalberto H Sousa, Paulo R Cecon, Marcela S Carvalho   +4 more
doaj   +1 more source