Results 1 to 10 of about 3,038,058 (339)

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

Metabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai, Xiaohui Dai, Xingang Miao, Bing Xie, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +7 more
doaj   +1 more source

CCK1R2R-/- ameliorates myocardial damage caused by unpredictable stress via altering fatty acid metabolism

Stress, 2023
The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism.
Zhi-Hua Zhang, Chen-Teng Yang, Xiao-Rui Su, Ya-Ping Li, Xiao-Jing Zhang, Song-Jun Wang, Bin Cong   +6 more
doaj   +1 more source

Inhibitory Effect of CCK-8 on Methamphetamine-Induced Apoptosis

Fayixue Zazhi, 2021
ObjectiveTo investigate the inhibitory effect of cholecystokinin octapeptide （CCK-8） binding to cholecystokinin 2 receptor （CCK2R） on methamphetamine （METH）-induced neuronal apoptosis, and to explore the signal transduction mechanism of β-arrestin 2 in ...
ZHANG Wu-hua, ZHANG Ming-long, JING Wei-wei, XIE Bing, BI Hai-tao, YU Feng, CONG Bin, MA Chun-ling, WEN Di   +8 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells

Analytical Cellular Pathology, 2021
Objective. The present study selected PC12 cells to construct a neuronal injury model induced by glucocorticoids (GC) in vitro, aiming to explore whether the endoplasmic reticulum stress (ERS) PKR-like endoplasmic reticulum kinase (PERK)-activating ...
Shanyong Yi, Weibo Shi, Min Zuo, Songjun Wang, Rufei Ma, Haitao Bi, Bin Cong, Yingmin Li   +7 more
doaj   +1 more source

The Pathology of Morphine-Inhibited Nerve Repair and Morphine-Induced Nerve Damage Is Mediated via Endoplasmic Reticulum Stress

Frontiers in Neuroscience, 2021
ObjectiveThe aim of the present study was to observe the pathological damage in the cerebral cortex of rats under acute morphine exposure (AME) and different durations of morphine dependence (MD), explore whether endoplasmic reticulum stress (ERS) is ...
Jie Liu, Jie Liu, Shanyong Yi, Shanyong Yi, Weibo Shi, Guozhong Zhang, Songjun Wang, Qian Qi, Bin Cong, Yingmin Li   +9 more
doaj   +1 more source

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Scientific Reports, 2023
This study differentiates myocardial infarction (MI) and strangulation death (STR) from the perspective of amino acid metabolism. In this study, MI mice model via subcutaneous injection of isoproterenol and STR mice model by neck strangulation were ...
Song-Jun Wang, Bing-Rui Liu, Fu Zhang, Xiao-Rui Su, Ya-Ping Li, Chen-Teng Yang, Zhi-Hua Zhang, Bin Cong   +7 more
doaj   +1 more source

A Metabolomics-Based Study on the Discriminative Classification Models and Toxicological Mechanism of Estazolam Fatal Intoxication

Metabolites, 2023
Fatal intoxication with sedative-hypnotic drugs is increasing yearly. However, the plasma drug concentration data for fatal intoxication involving these substances are not systematic and even overlap with the intoxication group.
Xiaohui Dai, Rui Bai, Bing Xie, Jiahong Xiang, Xingang Miao, Yan Shi, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +9 more
doaj   +1 more source

Epidemiological Characteristics of Sedative-Hypnotics and Opioid Painkillers at High-Frequency Exposure

Fayixue Zazhi, 2021
Drug poisoning has a high incidence and serious consequences in medical institutions; its epidemiological characteristics also directly affect the changes in national laws and policies and the implementation of local management policies.
BAI Rui, XIE Bing, CONG Bin, MA Chun-ling, WEN Di   +4 more
doaj   +1 more source

Analysis of Five Mushroom Toxins in Blood by UPLC-HRMS

Fayixue Zazhi, 2021
ObjectiveTo develop a method for the simultaneous and rapid detection of five mushroom toxins （α-amanitin， phallacidin， muscimol， muscarine and psilocin） in blood by ultra-high performance liquid chromatography-high resolution mass spectrometry （UPLC ...
LIU Wen-qiao, SHI Yan, XIANG Ping, YU Feng, XIE Bing, DONG Mei, HA Jing, MA Chun-ling, WEN Di   +8 more
doaj   +1 more source

Research Progress and Forensic Application of Postmortem Genetic Testing in Hereditary Cardiac Diseases

Fayixue Zazhi, 2022
Hereditary cardiac disease accounts for a large proportion of sudden cardiac death （SCD） in young adults. Hereditary cardiac disease can be divided into hereditary structural heart disease and channelopathies.
DONG Yi-ming, YANG Chen-teng, ZHANG Guo-zhong, CONG Bin   +3 more
doaj   +1 more source