Results 171 to 180 of about 706,415 (288)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Elastic analysis bridges structure and dynamics of an AAA+ molecular motor. [PDF]

PLoS Comput Biol
Mello VH, Wald J, Marlovits TC, Sartori P.   +3 more
europepmc   +1 more source

A visible-light-driven molecular motor based on barbituric acid. [PDF]

Chem Sci, 2023
Kuntze K, Pooler DRS, Di Donato M, Hilbers MF, van der Meulen P, Buma WJ, Priimagi A, Feringa BL, Crespi S.   +8 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Molecular motor-driven reversible liquid-liquid phase separation of supramolecular assemblies. [PDF]

Nat Commun
Xu F, Ovalle M, Fu Y, Stuart MAC, Feringa BL.   +4 more
europepmc   +1 more source

Author Correction: Towards the engineering of a photon-only two-stroke rotary molecular motor. [PDF]

Nat Commun, 2022
Filatov Gulak M, Paolino M, Pierron R, Cappelli A, Giorgi G, Léonard J, Huix-Rotllant M, Ferré N, Yang X, Kaliakin D, Blanco-González A, Olivucci M.   +11 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A Catalysis-Driven Dual Molecular Motor. [PDF]

J Am Chem Soc
Wang PL, Olivieri E, Borsley S, Whitehead GFS, Hasija A, Leigh DA.   +5 more
europepmc   +1 more source

Binding partners regulate unfolding of myosin VI to activate the molecular motor. [PDF]

Biochem J, 2022
Dos Santos Á, Fili N, Hari-Gupta Y, Gough RE, Wang L, Martin-Fernandez M, Aaron J, Wait E, Chew TL, Toseland CP.   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source