Results 181 to 190 of about 4,509,513 (302)

Cytoskeletal Dynamics and Molecular Motor Dysfunction in Psychiatric Disorders: Insights from Schizophrenia and Autism Spectrum Disorder. [PDF]

Biology (Basel)
Nakamura K, Kubo A, Sanaka S, Kamiya S, Itagaki K, Sasaki T.   +5 more
europepmc   +1 more source

Long-Time Dynamics of Selected Molecular-Motor Components Using a Physics-Based Coarse-Grained Approach. [PDF]

Biomolecules, 2023
Liwo A, Pyrka M, Czaplewski C, Peng X, Niemi AJ.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ford Motor Company folder of promotional materials, Seattle World's Fair, 1962

, 1962
Includes an information sheet which provides an overview of the Ford Display Pavilion, its location on the Century 21 Exposition fairgrounds, and the names of those involved in its design and construction; press releases detailing the Ford Pavilion's ...
Ford Motor Company
core  

Multi-Stimulus Triggered Programmable Transformation of Molecular Motor Based Chiral Supramolecular Polymers in Water. [PDF]

Angew Chem Int Ed Engl
Wang J, Stuart MCA, Feringa BL.
europepmc   +1 more source

Synergistic interplay between photoisomerization and photoluminescence in a light-driven rotary molecular motor. [PDF]

Nat Commun, 2022
Toyoda R, Hoang NV, Moghaddam KG, Crespi S, Pooler DRS, Faraji S, Pshenichnikov MS, Feringa BL.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Elastic analysis bridges structure and dynamics of an AAA+ molecular motor. [PDF]

PLoS Comput Biol
Mello VH, Wald J, Marlovits TC, Sartori P.   +3 more
europepmc   +1 more source

A visible-light-driven molecular motor based on barbituric acid. [PDF]

Chem Sci, 2023
Kuntze K, Pooler DRS, Di Donato M, Hilbers MF, van der Meulen P, Buma WJ, Priimagi A, Feringa BL, Crespi S.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source