Results 181 to 190 of about 358,120 (301)

F₁F_O ATP synthase molecular motor mechanisms. [PDF]

Front Microbiol, 2022
Frasch WD, Bukhari ZA, Yanagisawa S.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Long-Time Dynamics of Selected Molecular-Motor Components Using a Physics-Based Coarse-Grained Approach. [PDF]

Biomolecules, 2023
Liwo A, Pyrka M, Czaplewski C, Peng X, Niemi AJ.   +4 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Multi-Stimulus Triggered Programmable Transformation of Molecular Motor Based Chiral Supramolecular Polymers in Water. [PDF]

Angew Chem Int Ed Engl
Wang J, Stuart MCA, Feringa BL.
europepmc   +1 more source

Synergistic interplay between photoisomerization and photoluminescence in a light-driven rotary molecular motor. [PDF]

Nat Commun, 2022
Toyoda R, Hoang NV, Moghaddam KG, Crespi S, Pooler DRS, Faraji S, Pshenichnikov MS, Feringa BL.   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Elastic analysis bridges structure and dynamics of an AAA+ molecular motor. [PDF]

PLoS Comput Biol
Mello VH, Wald J, Marlovits TC, Sartori P.   +3 more
europepmc   +1 more source

A visible-light-driven molecular motor based on barbituric acid. [PDF]

Chem Sci, 2023
Kuntze K, Pooler DRS, Di Donato M, Hilbers MF, van der Meulen P, Buma WJ, Priimagi A, Feringa BL, Crespi S.   +8 more
europepmc   +1 more source

Clinical neurophysiology of motor neuron diseases /

, 2004
Includes bibliographical references and index.Print version record.Foreword. List of Contributors. 1. Overview (A. Eisen).I. Anatomy and Physiology of the Human Motor System. 2. Comparative anatomy of the motor system: differences in the organization of
Eisen, Andrew
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