Results 71 to 80 of about 395,686 (301)

Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. [PDF]

, 2016
The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation.
Jin, Yishi, Takayanagi-Kiya, Seika
core   +2 more sources

Construction of a Chassis for a Tripartite Protein-Based Molecular Motor [PDF]

ACS Synthetic Biology, 2017
Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors.
Lara S. R. Small, Marc Bruning, Andrew R. Thomson, Aimee L. Boyle, Roberta B. Davies, Paul M. G. Curmi, Nancy R. Forde, Heiner Linke, Derek N. Woolfson, Elizabeth H. C. Bromley   +9 more
openaire   +6 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Structural and molecular changes in the epicenter of injury and distant segments of the rat spinal cord in response to rehabilitative motor training

Acta Biomedica Scientifica
Background. Spinal cord injury (SCI) leads to partial or complete loss of sensory and/or  motor functions below the injury site due to neuron and glial cell death, axonal degeneration, and disruption of the blood-spinal cord barrier (BSCB).
D. Kh. Sabirov, T. V. Ageeva, A. V. Timofeeva, E. A. Plotnikova, S. S. Arkhipova, E. F. Davletshin, Ya. O. Mukhamedshina   +6 more
doaj   +1 more source

Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Neurobiology of Disease, 2011
Expression of mutant SOD1 typical of familial amyotrophic lateral sclerosis (ALS) induces the expression of Bcl2-A1, a member of the Bcl2 family of proteins, specifically in motor neurons of transgenic mice.In this work, we have used immortalized motor ...
Ciro Iaccarino, Maria Elena Mura, Sonia Esposito, Franco Carta, Giovanna Sanna, Franco Turrini, Maria Teresa Carrì, Claudia Crosio   +7 more
doaj   +1 more source

Transport by molecular motors in the presence of static defects [PDF]

, 2009
The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and unbinding from the
A. Ebneth, A. Parmeggiani, A. Seitz, A. Seitz, A.B. Kolomeisky, B. Schmittmann, B.M. Paschal, C. Leduc, E.-M. Mandelkow, G. Tripathy, G.A. Klein, G.M. Schütz, H. Hagiwara, H. Hess, I.M. Crevel, J. Beeg, J. Howard, J. Krug, J.-C. Larcher, J.C. Bulisnki, K. Nishinari, K. Tokuraku, L.A. Lopez, L.J. Davis, L.S.B. Goldstein, M. Vershinin, M. Vershinin, M.G.L. Heuvel Van den, M.J.I. Müller, M.J.I. Müller, M.R. Evans, N. Mirin, N.A. Reed, P. Pierobon, R. Dixit, R. Lipowsky, R. Lipowsky, R. Sato-Harada, Reinhard Lipowsky, S. Heins, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Konzack, S. Lakämper, S.A. Janowsky, Stefan Klumpp, T.M. Nieuwenhuizen, Yan Chai   +52 more
core   +3 more sources

The Lawnmower: an autonomous, protein-based artificial molecular motor

arXiv:2109.10293 [physics.bio-ph], 2021
Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by Nature - to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular ...
Korosec, Chapin S., Unksov, Ivan, Surendiran, Pradheebha, Lyttleton, Roman, Curmi, Paul M. G., Angstmann, Christopher N., Eichhorn, Ralf, Linke, Heiner, Forde, Nancy R.   +8 more
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Proteomic analysis illustrates the potential involvement of motor proteins in cleft palate development

Scientific Reports
Cleft palate (CP) is a congenital condition characterized by a complex etiology and limited diagnostic and therapeutic options. In this study, we delved into the molecular mechanisms associated with retinoic acid (RA)-induced CP in Kun Ming mice ...
Zijian Huang, Chuzhao Zhang, Meng Sun, Aiwei Ma, Liyun Chen, Wenshi Jiang, Mengjing Xu, Xujue Bai, Jianda Zhou, Wancong Zhang, Shijie Tang   +10 more
doaj   +1 more source

Hsp70 at the membrane: driving protein translocation

BMC Biology, 2018
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—such as those in the membranes of the ...
Elizabeth A. Craig
doaj   +1 more source