Arachis hypogaea monoacylglycerol lipase AhMAGL3b participates in lipid metabolism [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) belongs to the serine hydrolase family; it catalyzes MAG to produce glycerol and free fatty acids (FFAs), which is the final step in triacylglycerol (TAG) hydrolysis.
Yihua Zhan +4 more
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Monoacylglycerol Lipase Regulates Fever Response. [PDF]
PLoS ONE, 2015 Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2).
Manuel Sanchez-Alavez +7 more
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Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex [PDF]
Nature Communications, 2023 The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures.
Nikos Pinotsis +9 more
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Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration [PDF]
JHEP Reports, 2023 Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and ...
Manon Allaire +15 more
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Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.) [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.
Zhibin Zhou +7 more
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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
PLoS ONE, 2022 Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammatory stimuli
Alicia M. Kemble +10 more
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Future Foods, 2021 Pure concentrates of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were used to produce monoacylglycerol and diacylglycerol (MDG) oils via enzymatic glycerolysis in a solvent-free system. Immobilized lipase from Candida antarctica B (Novozym 435)
Tharuka Gunathilake +2 more
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Association of MGLL Intronic C>T Single Nucleotide Polymorphism (rs782440) with Borderline Personality Disorder: A Case-Control Study [PDF]
Cell Journal, 2023 Objective: From the perspective of etiology, borderline personality disorder (BPD) is a multifactorial and complexdisorder, hence our understanding about the molecular basis and signaling of this disorder is extremely limited.The purpose of this study ...
Nazanin Hatami Bavarsad +7 more
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Metabolites, 2020 The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose ...
Peter Hofer +4 more
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Hydrolysis of rat chylomicron acylglycerols: a kinetic model
Journal of Lipid Research, 1981 A quantitative model describing the kinetics of hydrolysis of rat chylomicron acylglycerols by bovine milk lipoprotein lipase has been developed using data from studies on rat lymph chylomicrons containing doubly labeled acylglycerols.
D M Foster, M Berman
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