Results 11 to 20 of about 9,642 (173)
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. [PDF]
ACS Med Chem Lett, 2022 Sabnis RW.
europepmc +4 more sources
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Cell Reports, 2012 Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression.
Rongqing Chen +7 more
doaj +5 more sources
Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors. [PDF]
ACS Med Chem Lett, 2021 Sabnis RW.
europepmc +4 more sources
Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders. [PDF]
ACS Med Chem Lett, 2023 Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.
Sabnis RW, Sabnis AR.
europepmc +3 more sources
Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors. [PDF]
ACS Med Chem Lett, 2021 Sabnis RW.
europepmc +4 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. [PDF]
J Med Chem, 2022 Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols. Many studies demonstrated beneficial effects deriving from MAGL inhibition for neurodegenerative diseases, inflammatory pathologies, and cancer.
Bononi G +19 more
europepmc +6 more sources
Therapeutic potential of monoacylglycerol lipase inhibitors [PDF]
Life Sciences, 2013 Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and inflammation. Both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating cannabinoid receptors, and cyclooxygenase (COX) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown ...
Melinda M, Mulvihill, Daniel K, Nomura
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Assay of Monoacylglycerol Lipase Activity [PDF]
, 2016 Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). 2-AG is one of the main endogenous lipid agonists for cannabinoid receptors in the brain and elsewhere in the body.
Jung, Kwang-Mook, Piomelli, Daniele
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Inhibition of monoacylglycerol lipase reduces nicotine withdrawal [PDF]
British Journal of Pharmacology, 2015 Background and PurposeAbrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine‐dependent animals, consisting of somatic and affective signs, avoidance of which contributes to drug maintenance.
P P, Muldoon +9 more
openaire +2 more sources