Results 51 to 60 of about 11,083 (203)

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor [PDF]

, 2019
Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes.
Carlotta Granchi (1375599), Granchi, Carlotta, El Boustani, Maguie, Cristina Licari (6319949), Margherita Lapillo (2931531), Tiziano Tuccinardi (409135), Minutolo, Filippo, Gertsch, Jürg, Giulio Poli (809754), Poli, Giulio, Sandra Glasmacher (6319943), Andrea Chicca (710770), Macchia, Marco, Glasmacher, Sandra, Chicca, Andrea, Lapillo, Margherita, Isabella Caligiuri (285374), Bononi, Giulia, Giulia Bononi (6319946), Marco Macchia (409137), Filippo Minutolo (1343184), Jürg Gertsch (1589107), Flavio Rizzolio (74629), Tuccinardi, Tiziano, Rizzolio, Flavio, Caligiuri, Isabella, Maguie el Boustani (6319952), Licari, Cristina   +27 more
core   +1 more source

Of Mice and MAGL (Monoacylglycerol Lipase)

The FASEB Journal, 2011
About 18.8 million American adults suffer depressive disorders that may occur with anxiety and substance abuse. Tetrahydrocannabinol (THC), a compound in marijuana, is a cannabinoid chemical that binds to and activates cannabinoid receptors (CB1) in the pre‐synaptic cell membrane as part of neuron‐to‐neuron transmission in the ...
S. Bach, T. Bombinski, M. Daniels, D. Gross, T. Hogg, T. Martin, D. McMurray, E. Naber, N. Perez, A. Schulman, S. Tucker, S. Andera‐Cato, A. Arnold, A. Blumberg, M. Bord, A. Feiertag, M. Greaves, A. Her, E. Kennedy, C. Orozco, C. Rice, A. Rodgers, A. Sauer, J. Schubert, C. Tubbs, T. Wray, G. Vogt, L. Shrestha, C. Hillard   +28 more
openaire   +1 more source

Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

Journal of Lipid Research, 2016
Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals.
Jose Iglesias, Julien Lamontagne, Heidi Erb, Sari Gezzar, Shangang Zhao, Erik Joly, Vouy Linh Truong, Kathryn Skorey, Sheldon Crane, S.R.Murthy Madiraju, Marc Prentki   +10 more
doaj   +1 more source

Monoacylglycerol lipase (MAGL) Inhibitors

, 2021
The present invention relates to compounds of formula (I) useful as inhibitors, in particular as reversible non-covalent inhibitors, of the enzyme monoacylglycerol lipase (MAGL). The present invention also relates to the therapeutic use of such compounds,
Poli G, Tuccinardi T, Macchia M, Minutolo F, Giordano A, Bononi G, Scalabrini D, Granchi C, Rizzolio F   +8 more
core  

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors [PDF]

, 2018
Monoacylglycerol lipase (MAGL) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid and glycerol.
Carlson, Kathryn E., Giannotti, Massimiliano, Chicca, Andrea, Lapillo, Margherita, Granchi, Carlotta, Katzenellenbogen, John A., Carlson, Kathryn E, Minutolo, Filippo, Kim, Sung Hoon, Bononi, Giulia, Poli, Giulio, Martinelli, Adriano, Katzenellenbogen, John A, Tuccinardi, Tiziano, Nieri, Daniela, Rizzolio, Flavio, Caligiuri, Isabella, Macchia, Marco, Boustani, Maguie El, Fortunato, Serena   +19 more
core   +1 more source

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]

, 2018
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes.
De Stefano L., Manera, Clementina, Rizzolio F., Margherita Lapillo, Gertsch, Jürg, Tuccinardi T., Baraldi, Stefania, Martinelli, Adriano, Filippo Minutolo, Macchia, Marco, De Stefano, Lucia, Lorenzo Di Cesare Mannelli, Carlotta Granchi, Stefania Baraldi, Martinelli A., Flavio Rizzolio, Carla Ghelardini, Di Cesare Mannelli, Lorenzo, Di Cesare Mannelli L., Ruggiero, Emanuela, Rizzolio, Flavio, Andrea Chicca, Gertsch J., Macchia M., Mojgan Aghazadeh Tabrizi, Lapillo M., Baraldi S., Granchi, Carlotta, Marco Macchia, Baraldi, Pier Giovanni, Minutolo, Filippo, Clementina Manera, Granchi C., Ghelardini, C, Baraldi P. G., Jürg Gertsch, Aghazadeh Tabrizi M., Lucia De Stefano, Aghazadeh Tabrizi, Mojgan, Di Cesare Mannelli, L, Emanuela Ruggiero, Adriano Martinelli, Chicca, Andrea, Pier Giovanni Baraldi, Lapillo, Margherita, Manera C., Chicca A., Ghelardini C., Tuccinardi, Tiziano, Ghelardini, Carla, Ruggiero E., Tiziano Tuccinardi, Minutolo F.   +52 more
core   +1 more source

Design‐Driven Production of Soybean Oil‐Based Structured Fats as Potential Substitutes for Palm‐Based Fats

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT This study examined whether enzymatic modification of soybean oil (SBO) can be tailored to produce trans‐free fats with physicochemical properties comparable to palm olein, stearin, or palm‐mid fractions (PMFs). US‐grown SBO was modified by lipase‐catalyzed acidolysis using palmitic acid at linearly interpolated substrate molar ratios (C16:0 ...
Ityotagher P. Aondoakaa, Silvana Martini, Casimir C. Akoh   +2 more
wiley   +1 more source

Biobased Polyurethane Films Based on Andiroba (Carapa guianensis) and Buriti (Mauritia flexuosa) Oil Polyols

Journal of Applied Polymer Science, EarlyView.
Polyurethane films were prepared from andiroba (Carapa guianensis) and buriti (Mauritia flexuosa) oil‐derived polyols, emphasizing their potential as bio‐based materials. UV–Vis analysis indicates the retention of carotenoid‐related chromophoric features within the polymer matrix.
João A. P. da Silva, Amanda L. Ferreira, Felipe F. C. Tavares, Chana M. da Silva, Cesar L. Petzhold, Nilo S. M. Cardozo   +5 more
wiley   +1 more source

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

Conformational gating, dynamics and allostery in human monoacylglycerol lipase. [PDF]

Sci Rep, 2020
AbstractInhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can be aided by understanding the interplay between structure and dynamics.
Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A.   +11 more
europepmc   +4 more sources