Results 1 to 10 of about 10,352 (144)

Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status [PDF]

Antioxidants
Beneficial effects of the microbiota-derived metabolite butyrate at the colonic level are well established, particularly through its relevance in colorectal cancer (CRC) and inflammatory bowel disease (IBD), two major intestinal pathologies.
Fátima Martel
doaj   +2 more sources

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity [PDF]

Molecular Membrane Biology, 2006
Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70), ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for plasma membrane (PM) expression and activity. Here we use site-directed mutagenesis and expression in COS cells or Xenopus oocytes to investigate whether this glutamate (Glu218 in ...
Andrew Halestrap, Richard Sessions
exaly   +4 more sources

Lactylation landscape of mitochondrial proteins in myocardial infarction [PDF]

Redox Biology
Metabolic reprogramming is a hallmark of myocardial infarction (MI), in which cardiomyocytes shift from fatty acid oxidation to anaerobic glycolysis, leading to elevated lactate production and mitochondrial dysfunction. Lactylation, a recently discovered
Ashlesha Kadam, Shiridhar Kashyap, Kunal Samantaray, Natasha Jaiswal, Shanikumar Goyani, Philip A. Kramer, Pourhadi Hadi, Jingyun Lee, Cristina M. Furdui, Pooja Jadiya, Dhanendra Tomar   +10 more
doaj   +2 more sources

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome [PDF]

Scientific Reports, 2021
AbstractTreatment of locally advanced, unresectable head and neck squamous cell carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as standard of care. Prognostic features related to outcome upon RCT might be highly valuable to improve treatment.
Leu, Martin, Kitz, J., Pilavakis, Y., Hakroush, S., Wolff, H. A., Canis, M., Rieken, S., Schirmer, M. A., Leu, Martin; Clinic of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany, Kitz, J.; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany, Pilavakis, Y.; Clinic of Otorhinolaryngology, University Medical Center Göttingen, Göttingen, Germany, Hakroush, S.; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany, Wolff, H. A.; Department of Radiation Oncology, Medical Center, University of Regensburg, Regensburg, Germany, Canis, M.; Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Munich, Germany, Rieken, S.; Clinic of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany, Schirmer, M. A.; Clinic of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany   +15 more
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A rare thyroid disorder mimicking mitochondrial disease [PDF]

Biomedicinska istraživanja, 2021
Introduction. Patients affected with Allan-Herndon-Dudley syndrome (AHDS) have a deficiency of monocarboxylate transporter 8 (MCT8), a protein primarily responsible for the transport of triiodothyronine (T3) into the brain.
Adrijan Sarajlija, Sladjana Todorović, Biljana Alimpić, Maja Čehić   +3 more
doaj   +1 more source

Effects of weaning on regulators of volatile fatty acid absorption and intracellular pH in Holstein calves

JDS Communications, 2021
This study examined the effects of changes in rumen fermentation during the weaning transition on abundance of transporters involved in volatile fatty acid (VFA) absorption or intracellular pH homeostasis. Holstein bull calves (n = 27) were assigned to 1
Rebecca L. Hiltz, Dana E. McCurdy, Steven Moreland, Keith Klanderman, Anne H. Laarman   +4 more
doaj   +1 more source

Sodium-coupled monocarboxylate transporter 1 interacts with the RING finger- and PDZ domain-containing protein PDZRN3 [PDF]

The Journal of Physiological Sciences, 2019
Sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) mediates monocarboxylate transport in the proximal tubule of the kidney. We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which has a PDZ motif (Thr-Arg-Leu), by yeast two-hybrid screening and revealed that PDZK1 enhances the ...
Yusuke Otsuka, Tomomi Furihata, Kiyoshi Nakagawa, Yuta Ohno, Yoshie Reien, Motoshi Ouchi, Hidefumi Wakashin, Shuichi Tsuruoka, Naohiko Anzai   +8 more
openaire   +2 more sources

SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis

Vascular Biology, 2023
The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself also requires high levels of nutrient uptake as it develops to provide critical support for fetal ...
Ana Correia-Branco, Ariel Mei, Sreehari Pillai, Nirmala Jayaraman, Radhika Sharma, Alison G Paquette, Naveen K Neradugomma, Ciara Benson, Nicholas W Chavkin, Qingcheng Mao, Mary C Wallingford   +10 more
doaj   +1 more source

Differential Expression of Monocarboxylate Transporter 1 and Ancillary Protein CD147 in Red Blood Cells of Show Jumping Horses [PDF]

Journal of Equine Veterinary Science, 2017
We compare the expression levels of the lactate transporter complex consisting of the lactate transporter, monocarboxylate transporter 1 (MCT1), and its ancillary protein, cluster of differentiation 147 (CD147), in the membranes of red blood cells (RBCs) from two breeds of jumping horses and associate the expression levels of these proteins with their ...
Walter Heinz Feringer Júnior, Julia Ribeiro Garcia de Carvalho, Maria Luiza Mendes de Almeida, Eliana Gertrudes Macedo Lemos, Otávio Augusto Brioschi Soares, Gesiane Ribeiro, Antonio de Queiroz-Neto, Guilherme de Camargo Ferraz   +7 more
openaire   +4 more sources

Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability

Asian Journal of Pharmaceutical Sciences, 2020
Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang, Lichun Zhao, Qikun jiang, Yixin Sun, Dongyang Zhao, Mengchi Sun, Zhonggui He, Jin sun, Yang Wang   +8 more
doaj   +1 more source