Results 11 to 20 of about 10,352 (144)
eLife, 2023 Wolfram syndrome 1 (WS1) is a rare genetic disorder caused by mutations in the WFS1 gene leading to a wide spectrum of clinical dysfunctions, among which blindness, diabetes, and neurological deficits are the most prominent.
Greta Rossi +13 more
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Down-regulation of monocarboxylate transporter 1 (MCT1) gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling [PDF]
British Journal of Nutrition, 2015 The present study investigated the influence of bacterial metabolites on monocarboxylate transporter 1 (MCT1) expression in pigs usingin vivo,ex vivoandin vitroapproaches. Piglets (n24) were fed high-protein (26 %) or low-protein (18 %) diets with or without fermentable carbohydrates. Colonic digesta samples were analysed for a broad range of bacterial
Carmen, Villodre Tudela +6 more
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Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2023 Monocarboxylate transporter 1 (MCT1; SLC16A1) is a proton-dependent cotransporter/exchanger, located on the apical membrane of cells.
Celal Bulğay +5 more
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gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans [PDF]
Genetics, 2009 Abstract The gon-2 gene of Caenorhabditis elegans encodes a TRPM cation channel required for gonadal cell divisions. In this article, we demonstrate that the gonadogenesis defects of gon-2 loss-of-function mutants (including a null allele) can be suppressed by gain-of-function mutations in the gem-1 (gon-2extragenic modifier) locus.
Benedict J, Kemp +4 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
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Cancer & Metabolism, 2022 Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions.
Tia R. Tidwell +4 more
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The FASEB Journal, 2019 Solute carrier (SLC) transporters are a superfamily of membrane bound proteins with over 300 identified members. These proteins serve as key regulators of cellular homeostasis by facilitating substrate entry and by‐product elimination across the plasma membrane. Dysregulation of SLC transporter function contributes to numerous diseases such as diabetes,
T. Liz Bailey +2 more
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The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrupts Rat Lung Branching
Cellular Physiology and Biochemistry, 2013 Background/Aims: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate.
Sara Granja +7 more
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The role of the genetic factor of lactate transport in endurance sports
Здоров’я, спорт, реабілітаціяBackground and purpose With the growth of sports results, more and more attention is paid to identifying the role of genetic factors in various metabolic processes. One of these factors is the protein responsible for the transport of lactate.
Rafia Fathi +4 more
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Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver
Journal of Pharmacy & Pharmaceutical Sciences, 2019 Purpose: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such
Michael Ng +3 more
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