Results 21 to 30 of about 10,352 (144)

Chronic Post-Exercise Lactate Administration with Endurance Training Increases Glycogen Concentration and Monocarboxylate Transporter 1 Protein in Mouse White Muscle

Journal of Nutritional Science and Vitaminology, 2014
Lactate is oxidized as an energy fuel during exercise, and it also plays a key role in the regulation of glycogen synthesis in the muscles and liver after exercise. Previous studies have suggested that lactate is converted to glycogen and stimulates glycogen synthesis. However, it remains unclear whether chronic post-exercise lactate administration can
HOSHINO, Daisuke, HANAWA, Tatsuya, TAKAHASHI, Yumiko, MASUDA, Hiroyuki, KATO, Mai, HATTA, Hideo   +5 more
openaire   +3 more sources

Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation [PDF]

Diabetes & Metabolism Journal
Background Lactate, traditionally considered a metabolic byproduct, is increasingly recognized as a signaling molecule involved in metabolic regulation.
Giang Nguyen, Ji Hee Yu, Phuc Thi Minh Pham, Thuy Linh Lai, So Young Park, Ki Woo Kim, Seung-Soon Im, Jeana Hong, Yong-ho Lee, Jae-Ho Lee, Seon Mee Kang, Dae-Hee Choi, Eun-Hee Cho   +12 more
doaj   +1 more source

Protein-Protein Interaction between Sodium-Coupled Monocarboxylate Transporter 1 (SMCT1) and PDZ Domain-Containing Ring Finger Domain 3 (PDZRN3) [PDF]

Biophysical Journal, 2017
Sodium-coupled monocarboxylate transporters (SMCTs) are membrane proteins which transport lactate on the apical side of kidney. In addition to renal lactate reabsorption, it is known that both SMCTs and urate/anion transporter1 (URAT1) bind to PDZK1 and that SMCTs and URAT1 functionally cooperate to transport urate.
openaire   +1 more source

Effect of Curcumin on SMCT-1 Expression and Dichloroacetate Toxicity in HCT116 Colon Cancer Cells

Pharmaceutical Sciences, 2017
Background: Colorectal cancer is a common cause of cancer-related deaths Epigenetic regulation of the influx sodium dependent monocarboxylate transporter-1 )SMCT1), a tumor suppressor, was recognized in colorectal cancer.
Torsak Intaraphairot, Chatchai Chinpaisal, Auayporn Apirakaramwong
doaj   +1 more source

Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2

European Journal of Pharmaceutical Sciences, 2015
Hesperetin, the aglycone of hesperidin, occurs naturally in citrus fruits. It exerts extensive pharmacological activities. However, hesperetin's poor solubility and low bioavailability limit its wide application. In order to overcome these limitations, recently a series of novel hesperitin derivatives containing Mannich base moieties were synthesized ...
Chenlin, Shen, Ruonan, Chen, Zhengyue, Qian, Xiaoming, Meng, Tingting, Hu, Yangyang, Li, Zhaolin, Chen, Cheng, Huang, Chaojie, Hu, Jun, Li   +9 more
openaire   +2 more sources

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells.
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu   +10 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Candidate genes for performance in horses, including monocarboxylate transporters

Pesquisa Veterinária Brasileira
: Some horse breeds are highly selected for athletic activities. The athletic potential of each animal can be measured by its performance in sports. High athletic performance depends on the animal capacity to produce energy through aerobic and anaerobic ...
Inaê Cristina Regatieri, Rogério Abdallah Curi, Guilherme de Camargo Ferraz, Antonio de Queiroz-Neto   +3 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

The use of the SLC16A1 gene as a potential marker to predict race performance in Arabian horses

BMC Genetics, 2019
Background Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes.
Katarzyna Ropka-Molik, Monika Stefaniuk-Szmukier, Tomasz Szmatoła, Katarzyna Piórkowska, Monika Bugno-Poniewierska   +4 more
doaj   +1 more source