Results 161 to 170 of about 13,009 (197)

Monocarboxylate transporter MCT1 is a target for immunosuppression

Nature Chemical Biology, 2005
Current immunosuppressive therapies act on T lymphocytes by modulation of cytokine production, modulation of signaling pathways or by inhibition of the enzymes of nucleotide biosynthesis. We have identified a previously unknown series of immunomodulatory compounds that potently inhibit human and rat T lymphocyte proliferation in vitro and in vivo in ...
Clare M, Murray, Raymond, Hutchinson, John R, Bantick, Graham P, Belfield, Amanda D, Benjamin, Diana, Brazma, Robert V, Bundick, I David, Cook, Robert I, Craggs, Susan, Edwards, Leslie R, Evans, Richard, Harrison, Elain, Holness, Andrew P, Jackson, Clive G, Jackson, Lee P, Kingston, Matthew W D, Perry, Andrew R J, Ross, Paul A, Rugman, Sasvinder S, Sidhu, Michael, Sullivan, David A, Taylor-Fishwick, P Craig, Walker, Yvonne M, Whitehead, David J, Wilkinson, Andrew, Wright, David K, Donald   +26 more
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The neuroimaging findings of monocarboxylate transporter 1 deficiency

Neuroradiology, 2020
Monocarboxylate transporter 1 (MCT1) deficiency was first described in 2014 by Hasselt et al. as a novel genetic cause of recurrent ketoacidosis. Patients present in the first year of life with acute episodes of ketoacidosis triggered by fasting or infections.
Manal Nicolas-Jilwan, Rita Medlej, Raashda A Sulaiman, Moeenaldeen AlSayed   +3 more
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Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters

Metabolism, 2002
Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for
Guillaume, Py, Karen, Lambert, Ollivier, Milhavet, Nicolas, Eydoux, Christian, Préfaut, Jacques, Mercier   +5 more
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Monocarboxylate Transporters are not Responsible for Cr3+ Transport from Endosomes

Biological Trace Element Research, 2012
Cr(3+), similar to Fe(3+), is transported into cells primarily via endocytosis as the metal-transferrin complex. As Cr(3+) ions are not readily reduced under biological conditions, the ion cannot be transported from endosomes by the same mechanism as iron that utilized divalent metal ion transporters.
Nicholas R, Rhodes, Paul A, LeBlanc, Jane F, Rasco, John B, Vincent   +3 more
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Functional characteristics of the cardiac sarcolemmal monocarboxylate transporter

The Journal of Membrane Biology, 1989
We have previously shown that a mechanism for transporting L-lactate is located in cardiac sarcolemmal membranes (Am. J. Physiol. 252:C483-C489, 1987). This mechanism has now been shown to transport pyruvate also. The transporter recognizes a wide range of monocarboxylic acids with chain lengths of three to six carbons, as evidenced by their ability to
T L, Trosper, K D, Philipson
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Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859

European Journal of Pharmacology, 2015
The synthetic compound N-cyanosulphonamide S0859 has been described as a selective inhibitor of sodium-bicarbonate cotransporters (NBC, SLC4) in mammalian heart (Ch'en et al., 2008). First, for comparison, the electrogenic human NBCe1 (SLC4A4) was heterologously expressed in Xenopus laevis oocytes, where its transport activity was inhibited by S0859 ...
Hella, Heidtmann, Iván, Ruminot, Holger M, Becker, Joachim W, Deitmer   +3 more
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Expression of monocarboxylate transporters in rat ocular tissues

American Journal of Physiology-Cell Physiology, 2005
The aim of the present study was to determine the distribution of monocarboxylate transporter (MCT) subtypes 1-4 in the various structures of the rat eye by using a combination of conventional and real-time RT-PCR, immunoblotting, and immunohistochemistry. Retinal samples expressed mRNAs encoding all four MCTs.
Glyn, Chidlow, John P M, Wood, Mark, Graham, Neville N, Osborne   +3 more
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Transport of Hexoses and Monocarboxylic Acids

1983
Although the dependence of the mammalian brain, under normal conditions, on a regular supply of glucose from the bloodstream has been acknowledged for 50 years or more, ways by which glucose passes to the brain and how it travels within the brain were ignored until relatively recently.
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Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

Cell, 2021
Nan Wang, Chuangye Yan, Shuo Zhang
exaly  

Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes

American Journal of Physiology - Renal Physiology, 2021
Ken-Ichi Hosoya, Masanori Tachikawa, Yoshiyuki Kubo   +2 more
exaly