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Pharmacology & Therapeutics, 2021
Human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) are involved in the proton-dependent transport of monocarboxylates such as L-lactate, which play an essential role in cellular metabolism and pH regulation. hMCT1 and 4 are overexpressed in a number of cancers, and polymorphisms in hMCT1 have been reported to be associated with the prognosis of ...
Masaki, Kobayashi +3 more
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Human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) are involved in the proton-dependent transport of monocarboxylates such as L-lactate, which play an essential role in cellular metabolism and pH regulation. hMCT1 and 4 are overexpressed in a number of cancers, and polymorphisms in hMCT1 have been reported to be associated with the prognosis of ...
Masaki, Kobayashi +3 more
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Monocarboxylate transporter 1 is a key player in glioma‐endothelial cell crosstalk
Molecular Carcinogenesis, 2017Glioblastoma (GBM) is one of the most glycolytic and angiogenic human tumors, characteristics that contribute to the poor prognosis associated with this type of tumor. A lactate shuttle has been described between tumor cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) acting as important players in this tumor‐EC ...
Vera Miranda‐Gonçalves +8 more
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Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors
Virchows Archiv, 2012Emmprin is a transmembrane glycoprotein known as a matrix metalloproteinase inducer and is highly up-regulated in malignant cancer cells. The monocarboxylate transporters (MCTs) are responsible for H(+)-linked transport of monocarboxylates across the cell membrane.
Miyoko, Fukuoka +7 more
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Research in Veterinary Science, 2005
In the present study the expression and distribution of monocarboxylate transporter 1 (MCT1) along the gastrointestinal tract (rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, cecum and colon) of calves were investigated on both mRNA and protein levels. The expression of MCT1 protein and its distribution were determined by Western blotting
D, Kirat +6 more
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In the present study the expression and distribution of monocarboxylate transporter 1 (MCT1) along the gastrointestinal tract (rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, cecum and colon) of calves were investigated on both mRNA and protein levels. The expression of MCT1 protein and its distribution were determined by Western blotting
D, Kirat +6 more
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Monocarboxylate transporter 1 (MCT1) in the liver of pre-ruminant and adult bovines
The Veterinary Journal, 2007This study investigated the distribution and expression of monocarboxylate transporter 1 (MCT1) in the livers of pre-ruminant calves and adult bovines (bulls and cows), using different molecular biological techniques. Reverse transcription-polymerase chain reaction (RT-PCR) verified the presence of mRNA encoding for MCT1 in both pre-ruminant and adult ...
D, Kirat +5 more
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Role of the Monocarboxylate transporter 1 (MCT1) in T lymphocytes [PDF]
, 2020 Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
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Cancer Biotherapy and Radiopharmaceuticals
Objective: This study explored the role of monocarboxylate transporter 1 (MCT1) in nasopharyngeal carcinoma (NPC) metastasis and its regulation via DNA methyltransferase 3B (DNMT3B)-mediated methylation, to identify therapeutic targets for NPC. Methods: MCT1/DNMT3B expression was analyzed in NPC (n = 30) and normal tissues (n = 30) using quantitative ...
Weihong Tong +4 more
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Objective: This study explored the role of monocarboxylate transporter 1 (MCT1) in nasopharyngeal carcinoma (NPC) metastasis and its regulation via DNA methyltransferase 3B (DNMT3B)-mediated methylation, to identify therapeutic targets for NPC. Methods: MCT1/DNMT3B expression was analyzed in NPC (n = 30) and normal tissues (n = 30) using quantitative ...
Weihong Tong +4 more
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Structural Basis of Human Monocarboxylate Transporter 1 Inhibition by Anti-Cancer Drug Candidates
Cell, 2021Nan Wang, Chuangye Yan, Shuo Zhang
exaly