Results 181 to 190 of about 113,465,300 (217)

The neuroimaging findings of monocarboxylate transporter 1 deficiency

Neuroradiology, 2020
Monocarboxylate transporter 1 (MCT1) deficiency was first described in 2014 by Hasselt et al. as a novel genetic cause of recurrent ketoacidosis. Patients present in the first year of life with acute episodes of ketoacidosis triggered by fasting or infections.
Manal Nicolas-Jilwan, Rita Medlej, Raashda A Sulaiman, Moeenaldeen AlSayed   +3 more
openaire   +2 more sources

Cardiac and Skeletal Muscle Mitochondria Have a Monocarboxylate Transporter MCT1

Journal of Applied Physiology, 1999
To evaluate the potential role of monocarboxylate transporter-1 (MCT1) in tissue lactate oxidation, isolated rat subsarcolemmal and interfibrillar cardiac and skeletal muscle mitochondria were probed with an antibody to MCT1.
George A Brooks, Hervé Dubouchaud
exaly   +2 more sources

Monocarboxylate Transporter 1 in Brain Diseases and Cancers

Current Drug Metabolism, 2019
Background: Monocarboxylate Transporter 1 (MCT1), an important membrane transport protein, mediates the translocation of monocarboxylates together with protons across biological membranes. Due to its pathological significance, MCT1 plays an important role in the progression of some diseases, such as brain diseases and cancers.
Yixin Sun, Jin Sun, Zhonggui He, Gang Wang, Yang Wang, Dongyang Zhao, Zhenjie Wang, Cong Luo, Chutong Tian, Qikun Jiang   +9 more
openaire   +2 more sources

Monocarboxylate Transporter 1 Is Up-Regulated in Basal-Like Breast Carcinoma

Histopathology, 2010
Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, Schmitt F & Baltazar F
(2010) Histopathology   56, 860–867
 Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinoma
Bárbara Sousa, Joana Paredes, Fatima Baltazar   +2 more
exaly   +4 more sources

Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
Peroxisome proliferator-activated receptor (PPAR)-alpha mediates an adaptive response to fasting by up-regulation of genes involved in fatty acid oxidation and ketone body synthesis. Ketone bodies are transferred in and out of cells by monocarboxylate transporter (MCT)-1. In this study we observed for the first time that activation of PPARalpha in rats
Bettina, König, Alexander, Koch, Karen, Giggel, Batsuch, Dordschbal, Klaus, Eder, Gabriele I, Stangl   +5 more
openaire   +2 more sources

Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters

Metabolism, 2002
Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for
Guillaume, Py, Karen, Lambert, Ollivier, Milhavet, Nicolas, Eydoux, Christian, Préfaut, Jacques, Mercier   +5 more
openaire   +2 more sources

Expression of the monocarboxylate transporter 1 (MCT1) in cells of the porcine intestine

Cell Biology International, 2008
AbstractUptake of energy into cells and its allocation to individual cellular compartments by transporters are essential for tissue homeostasis. The present study gives an analysis of MCT1 expression and its cellular occurrence in the porcine intestine.
Harald, Welter, Rolf, Claus
openaire   +2 more sources

Monocarboxylate transporter 1 gene expression in the ovine gastrointestinal tract

The Veterinary Journal, 2006
In this study, we investigated the tissue distribution and expression of monocarboxylate transporter 1 (MCT1) along the gastrointestinal tract of sheep. Western blot analysis suggested the presence of MCT1 as a 43-kDa protein in immunoblots of membranes from the various tissues examined.
D, Kirat, H, Inoue, H, Iwano, K, Hirayama, H, Yokota, H, Taniyama, S, Kato   +6 more
openaire   +2 more sources

Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002
Due to intensive intracellular metabolism of short-chain fatty acids, ruminal epithelial cells generate large amounts of d-β-hydroxybutyric acid, acetoacetic acid, and lactic acid. These acids have to be extruded from the cytosol to avoid disturbances of intracellular pH (pHi). To evaluate acid extrusion, pHi was studied in cultured ruminal epithelial
Frank, Müller, Korinna, Huber, Helga, Pfannkuche, Jörg R, Aschenbach, Gerhard, Breves, Gotthold, Gäbel   +5 more
openaire   +2 more sources