Results 161 to 170 of about 12,791 (189)

Monocarboxylate transporter 1 gene expression in the ovine gastrointestinal tract

The Veterinary Journal, 2006
In this study, we investigated the tissue distribution and expression of monocarboxylate transporter 1 (MCT1) along the gastrointestinal tract of sheep. Western blot analysis suggested the presence of MCT1 as a 43-kDa protein in immunoblots of membranes from the various tissues examined.
D, Kirat, H, Inoue, H, Iwano, K, Hirayama, H, Yokota, H, Taniyama, S, Kato   +6 more
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Transport mechanism and drug discovery of human monocarboxylate transporter 1

Acta Pharmacologica Sinica
Human monocarboxylate transporters (MCTs) are crucial for tumour cell glycolysis. Inhibiting MCT-mediated lactate transport can suppress the proliferation of solid tumours and enhance the efficacy of the immune system against tumours. Despite the importance of this transporter, the molecular mechanism of lactate transport by MCT1 remains elusive ...
Sai, Shi, Jia-Chen, Li, Xiao-Yu, Zhou, Zhen-Lu, Li, Ya-Xin, Wang, Bing-Hong, Xu, Sheng, Ye   +6 more
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Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002
Due to intensive intracellular metabolism of short-chain fatty acids, ruminal epithelial cells generate large amounts of d-β-hydroxybutyric acid, acetoacetic acid, and lactic acid. These acids have to be extruded from the cytosol to avoid disturbances of intracellular pH (pHi). To evaluate acid extrusion, pHi was studied in cultured ruminal epithelial
Frank, Müller, Korinna, Huber, Helga, Pfannkuche, Jörg R, Aschenbach, Gerhard, Breves, Gotthold, Gäbel   +5 more
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Monocarboxylate transporter 1 is a key player in glioma‐endothelial cell crosstalk

Molecular Carcinogenesis, 2017
Glioblastoma (GBM) is one of the most glycolytic and angiogenic human tumors, characteristics that contribute to the poor prognosis associated with this type of tumor. A lactate shuttle has been described between tumor cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) acting as important players in this tumor‐EC ...
Vera Miranda‐Gonçalves, Filipa Bezerra, Raquel Costa‐Almeida, Marta Freitas‐Cunha, Raquel Soares, Olga Martinho, Rui M. Reis, Céline Pinheiro, Fátima Baltazar   +8 more
openaire   +3 more sources

Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors

Virchows Archiv, 2012
Emmprin is a transmembrane glycoprotein known as a matrix metalloproteinase inducer and is highly up-regulated in malignant cancer cells. The monocarboxylate transporters (MCTs) are responsible for H(+)-linked transport of monocarboxylates across the cell membrane.
Miyoko, Fukuoka, Makoto, Hamasaki, Kaori, Koga, Hiroyuki, Hayashi, Mikiko, Aoki, Tatsuhiko, Kawarabayashi, Shingo, Miyamoto, Kazuki, Nabeshima   +7 more
openaire   +2 more sources

Expression and distribution of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of calves

Research in Veterinary Science, 2005
In the present study the expression and distribution of monocarboxylate transporter 1 (MCT1) along the gastrointestinal tract (rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, cecum and colon) of calves were investigated on both mRNA and protein levels. The expression of MCT1 protein and its distribution were determined by Western blotting
D, Kirat, H, Inoue, H, Iwano, K, Hirayama, H, Yokota, H, Taniyama, S, Kato   +6 more
openaire   +2 more sources

Monocarboxylate transporter 1 (MCT1) in the liver of pre-ruminant and adult bovines

The Veterinary Journal, 2007
This study investigated the distribution and expression of monocarboxylate transporter 1 (MCT1) in the livers of pre-ruminant calves and adult bovines (bulls and cows), using different molecular biological techniques. Reverse transcription-polymerase chain reaction (RT-PCR) verified the presence of mRNA encoding for MCT1 in both pre-ruminant and adult ...
D, Kirat, H, Inoue, H, Iwano, H, Yokota, H, Taniyama, S, Kato   +5 more
openaire   +2 more sources

Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of γ-Hydroxybutyrate in Vitro and in Vivo

Drug Metabolism and Disposition, 2007
The objective of this study was to determine the effects of flavonoids on the in vitro monocarboxylate transporter 1 (MCT1)-mediated transport and in vivo disposition of the drug of abuse, gamma-hydroxybutyrate (GHB). The uptake of GHB in rat MCT1 gene-transfected MDA-MB231 cells was significantly decreased in the presence of the flavonoids apigenin ...
Qi, Wang, Marilyn E, Morris
openaire   +2 more sources

Role of the Monocarboxylate transporter 1 (MCT1) in T lymphocytes [PDF]

, 2020
Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
openaire  

Mechanism of Monocarboxylate Transporter 1 and Its Methylation in Nasopharyngeal Carcinoma Pathogenesis

Cancer Biotherapy and Radiopharmaceuticals
Objective: This study explored the role of monocarboxylate transporter 1 (MCT1) in nasopharyngeal carcinoma (NPC) metastasis and its regulation via DNA methyltransferase 3B (DNMT3B)-mediated methylation, to identify therapeutic targets for NPC. Methods: MCT1/DNMT3B expression was analyzed in NPC (n = 30) and normal tissues (n = 30) using quantitative ...
Weihong Tong, Zhengyong Zhu, Ruiyang Zhu, Zihe Wang, Jin Zhu   +4 more
openaire   +2 more sources