Results 141 to 150 of about 113,465,300 (217)

Monocarboxylate Transporter 1 May Benefit Cerebral Ischemia via Facilitating Lactate Transport From Glial Cells to Neurons. [PDF]

Front Neurol, 2022
Zhang M, Wang Y, Bai Y, Dai L, Guo H.
europepmc   +1 more source

Liquid Compared to Solid Oral Formulations of the Thyroid Hormone Receptor Agonist Elunetirom Under Fasted and Fed Conditions in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Elunetirom (ABX‐002) is a brain‐targeted, oral prodrug being developed for the adjunctive treatment of major depressive disorder and bipolar depression. The active moiety, LL‐340001, is a thyroid hormone receptor agonist with modest selectivity for beta over alpha thyroid hormone receptors. Upon entering the brain, the intended site of action,
Jason R. Harris, Aernout D. van Haarst, Jill Baccei, Bridgette Franey, Jason Everett, Kory George, Sabina Paglialunga, Kenneth Webster, Michelle Hillstrand, Chris Banfield, Thomas S. Scanlan, Gudarz Davar   +11 more
wiley   +1 more source

Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. [PDF]

J Clin Invest, 2021
Jha MK, Passero JV, Rawat A, Ament XH, Yang F, Vidensky S, Collins SL, Horton MR, Hoke A, Rutter GA, Latremoliere A, Rothstein JD, Morrison BM.   +12 more
europepmc   +1 more source

Acute exercise‐induced improvements in cognition: Role of cerebral blood flow and metabolism

Experimental Physiology, Volume 111, Issue 11, Page 5074-5082, 1 November 2026.
Abstract Physical activity is widely recognized for its ability to promote brain health, with acute exercise transiently enhancing cognition and long‐term training attenuating cognitive decline. However, the mechanisms underlying these benefits remain incompletely understood.
Takeshi Hashimoto, Shigehiko Ogoh
wiley   +1 more source

Inhibition of the Monocarboxylate Transporter 1 (MCT1) Promotes 3T3-L1 Adipocyte Proliferation and Enhances Insulin Sensitivity. [PDF]

Int J Mol Sci, 2022
Bailey T, Nieto A, McDonald P.
europepmc   +1 more source

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism. [PDF]

Antioxidants (Basel), 2023
Ammar N, Hildebrandt M, Geismann C, Röder C, Gemoll T, Sebens S, Trauzold A, Schäfer H.   +7 more
europepmc   +1 more source

Sodium-Coupled Monocarboxylate Transporter 1 [PDF]

, 2020
openaire   +1 more source

Monocarboxylate transporter 1 deficiency impacts CD8⁺ T lymphocytes proliferation and recruitment to adipose tissue during obesity. [PDF]

iScience, 2022
Macchi C, Moregola A, Greco MF, Svecla M, Bonacina F, Dhup S, Dadhich RK, Audano M, Sonveaux P, Mauro C, Mitro N, Ruscica M, Norata GD.   +12 more
europepmc   +1 more source

Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes. [PDF]

J Biol Chem, 2021
Lagarde D, Jeanson Y, Barreau C, Moro C, Peyriga L, Cahoreau E, Guissard C, Arnaud E, Galinier A, Bouzier-Sore AK, Pellerin L, Chouchani ET, Pénicaud L, Ader I, Portais JC, Casteilla L, Carrière A.   +16 more
europepmc   +1 more source

Monocarboxylate Transporter 1 Inhibitor AZD3965 [PDF]

, 2020
openaire   +1 more source