Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
Monocarboxylate transporter 1 deficiency impacts CD8<sup>+</sup> T lymphocytes proliferation and recruitment to adipose tissue during obesity. [PDF]
Macchi C +12 more
europepmc +1 more source
Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes. [PDF]
Lagarde D +16 more
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γ-Hydroxybutyric Acid-Ethanol Drug-Drug Interaction: Reversal of Toxicity with Monocarboxylate Transporter 1 Inhibitors. [PDF]
Rodriguez-Cruz V, Morris ME.
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Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors. [PDF]
Huang T +9 more
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Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma. [PDF]
Yokoo S +12 more
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Monocarboxylate transporter 1 (MCT1) in calf and sheep stomach [PDF]
D. Kirat +4 more
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