Results 111 to 120 of about 12,791 (189)

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism. [PDF]

Antioxidants (Basel), 2023
Ammar N, Hildebrandt M, Geismann C, Röder C, Gemoll T, Sebens S, Trauzold A, Schäfer H.   +7 more
europepmc   +1 more source

Monocarboxylate Transporter 1 [PDF]

, 2020
openaire   +1 more source

Monocarboxylate transporter 1 (MCT1) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 826-838, August 2026.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source

Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. [PDF]

J Clin Invest, 2021
Jha MK, Passero JV, Rawat A, Ament XH, Yang F, Vidensky S, Collins SL, Horton MR, Hoke A, Rutter GA, Latremoliere A, Rothstein JD, Morrison BM.   +12 more
europepmc   +1 more source

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 548-556, August 2026.
ABSTRACT Purpose 13C MRI with hyperpolarized [1‐13C]pyruvate enables noninvasive imaging of metabolic pathways. Considering the high dose of pyruvate used in hyperpolarized 13C‐pyruvate studies, circulating 13C‐pyruvate and the resulting 13C‐lactate in plasma may influence subsequent pyruvate metabolism, yet the guidance on consecutive injections does ...
Jun Chen, Sung‐Han Lin, Jessica Sudderth, Kelley A. Derner, Crystal E. Harrison, Maheen Zaidi, Jeannie D. Baxter, Jeff Liticker, Zohreh Erfani, Craig R. Malloy, Marco C. Pinho, Ralph J. DeBerardinis, Jae Mo Park   +12 more
wiley   +1 more source

Inhibition of the Monocarboxylate Transporter 1 (MCT1) Promotes 3T3-L1 Adipocyte Proliferation and Enhances Insulin Sensitivity. [PDF]

Int J Mol Sci, 2022
Bailey T, Nieto A, McDonald P.
europepmc   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice. [PDF]

Front Physiol, 2021
Martini T, Ripperger JA, Chavan R, Stumpe M, Netzahualcoyotzi C, Pellerin L, Albrecht U.   +6 more
europepmc   +1 more source