Results 111 to 120 of about 113,465,300 (217)
Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle.
, 1999 immunofluorescence microscopy; western blotting; monocarboxylate transporter; fiber ...
Pilegaard, Henriette +3 more
core +1 more source
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia +7 more
wiley +1 more source
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo +4 more
wiley +1 more source
, 2015 Transport of lactate, pyruvate and the ketone bodies acetoacetate and β-hydroxybutyrate, is mediated in most mammalian cells by members of the monocarboxylate transporter family (SLC16).
Broer, Stefan +4 more
core +1 more source
Zhongguo aizheng zazhi, 2019 Background and purpose: Monocarboxylate transporter 1 (MCT1) is commonly seen to be significantly overexpressed in cancer tissues that takes charge of transporting the lactate, pyruvate and their derivatives belonging to monocarboxylate in cells. However,
张 敏, 王琳娜, 孙 超
doaj
A Glial Interplay Regulates Junctional Architecture at the Blood–Brain Barrier of Drosophila
Glia, Volume 75, Issue 1, January 2027.Drosophila perineurial glia are required for septate junction formation at the blood–brain barrier. Glucose transport across the blood–brain barrier is maintained in the absence of perineurial glia. Perineurial glia ablation increases glucose‐only diet sensitivity.
Esteban G. Contreras +7 more
wiley +1 more source
Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1
, 2000 The short-chain fatty acid butyrate was readily taken up by Caco-2 cells. Transport exhibited saturation kinetics, was enhanced by low extracellular pH, and was Na+independent.
Pradeep K. Dudeja +4 more
core +1 more source
Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits
Glia, Volume 74, Issue 12, December 2026.To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom +11 more
wiley +1 more source