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Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer. [PDF]
BMC Clin Pathol, 2017 Latif A +11 more
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Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858. [PDF]
J Pharmacol Exp Ther, 2019 Follman KE, Morris ME.
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Monocarboxylate transporter 1 deficiency and ketone utilization
, 2015 van Hasselt, Peter M. +5 more
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Monocarboxylate Transporter 1 in Brain Diseases and Cancers
Current Drug Metabolism, 2019Background: Monocarboxylate Transporter 1 (MCT1), an important membrane transport protein, mediates the translocation of monocarboxylates together with protons across biological membranes. Due to its pathological significance, MCT1 plays an important role in the progression of some diseases, such as brain diseases and cancers.
Jin Sun, Yang Wang, Cong Luo
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Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinoma
Histopathology, 2010Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, Schmitt F & Baltazar F (2010) Histopathology 56, 860–867 Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinomaAims: Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate efflux in ...
Barbara Sousa +2 more
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The neuroimaging findings of monocarboxylate transporter 1 deficiency
Neuroradiology, 2020Monocarboxylate transporter 1 (MCT1) deficiency was first described in 2014 by Hasselt et al. as a novel genetic cause of recurrent ketoacidosis. Patients present in the first year of life with acute episodes of ketoacidosis triggered by fasting or infections.
Manal Nicolas-Jilwan +3 more
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Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008Peroxisome proliferator-activated receptor (PPAR)-alpha mediates an adaptive response to fasting by up-regulation of genes involved in fatty acid oxidation and ketone body synthesis. Ketone bodies are transferred in and out of cells by monocarboxylate transporter (MCT)-1. In this study we observed for the first time that activation of PPARalpha in rats
Bettina, König +5 more
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Metabolism, 2002
Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for
Guillaume, Py +5 more
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Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for
Guillaume, Py +5 more
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Expression of the monocarboxylate transporter 1 (MCT1) in cells of the porcine intestine
Cell Biology International, 2008AbstractUptake of energy into cells and its allocation to individual cellular compartments by transporters are essential for tissue homeostasis. The present study gives an analysis of MCT1 expression and its cellular occurrence in the porcine intestine.
Harald, Welter, Rolf, Claus
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