Results 201 to 210 of about 737,831 (351)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Antimicrobial therapy combined with C-C chemokine receptor type 2 modulation dampens mycobacteria-aggravated monocyte activation and atherosclerosis. [PDF]

Front Cardiovasc Med
Egoavil-Espejo R, Haller A, Feria MG, Jain SK, Singh M, Zhang B, Qualls JE, Hui DY, Huaman MA.   +8 more
europepmc   +1 more source

Supplementary Material for: Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages

, 2021
H. C., Aftab Nadeem, Browning K.L., Mario Campana, Artur Schmidtchen, vanderPlas M.J.A.   +5 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis. [PDF]

Sci Adv
Mukoyama H, Takeuchi Y, Ohara D, Lee Y, Watanabe H, Kato H, Kondoh G, Morinobu A, Hirota K.   +8 more
europepmc   +1 more source

Monocyte-platelet cross-talk in peripheral artery disease—how much does the pathogenesis of atherosclerosis depend on anatomical location? [PDF]

, 2019
Richard A. Brown, Gregory Y.H. Lip
openalex   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cells. [PDF]

Sci Rep
Cortés-Erice M, Garayo-Larrea A, Fernández-Ovejero R, Aubá E, Lizaso S, Aldaz P, Bes-Rastrollo M, Gil JL, Barrado L, Ortuño F, Molero P, Tordera RM.   +11 more
europepmc   +1 more source

Post-resistance exercise ingestion of milk protein attenuates plasma TNFα and TNFr1 expression on monocyte subpopulations

, 2017
Adam J. Wells, Adam R. Jajtner, Alyssa N. Varanoske, David D. Church, Adam M. Gonzalez, Jeremy R. Townsend, Carleigh H. Boone, Kayla M. Baker, Kyle S. Beyer, Gerald T. Mangine, Leonardo Oliveira, David H. Fukuda, Jeffrey R. Stout, Jay R. Hoffman   +13 more
openalex   +2 more sources

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source