Monomeric C-reactive protein as a biomarker for major depressive disorder [PDF]
Frontiers in Psychiatry, 2023 Neuroinflammation has been postulated to be a key factor in the pathogenesis of major depressive disorder (MDD). With this is mind, there has been a wave of research looking into pro-inflammatory mediators as potential biomarkers for MDD.
Mary G. Hornick, Lawrence A. Potempa
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Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Human study shows that elevated C‐reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD).
Qini Gan +8 more
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An ELISA Assay for Quantifying Monomeric C-Reactive Protein in Plasma [PDF]
Frontiers in Immunology, 2018 Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as a bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily as the monomeric conformation (mCRP) at ...
Lin Zhang +6 more
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Higher monomeric C-reactive protein levels are associated with premature coronary artery disease [PDF]
Frontiers in ImmunologyIntroductionChronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Ivan Melnikov +14 more
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Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis [PDF]
Frontiers in ImmunologyC-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao +15 more
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Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target [PDF]
Frontiers in Immunology, 2022 Monomeric C-reactive protein (mCRP), once thought to be a figment of the imagination and whose biological activity was ascribed to its sodium azide preservative, has now pronounced itself as a critical molecule playing a direct role in mediating many of ...
Mark Slevin +5 more
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Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein [PDF]
Frontiers in Immunology, 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an ...
Robert D. Williams +6 more
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Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia [PDF]
Biomedicines, 2021 Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
Elisa García-Lara +12 more
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The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2 [PDF]
Frontiers in Immunology, 2022 The receptor-binding domain (RBD) of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the human angiotensin-converting enzyme 2 (ACE2) receptor, which is a prerequisite for the virus to enter the cell. C-reactive
Hai-yun Li +9 more
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The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2022 The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov +15 more
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