Monomeric C-reactive protein and inflammation in age-related macular degeneration. [PDF]
J Pathol, 2016 AbstractAge‐related macular degeneration (AMD) is a devastating disease characterized by central vision loss in elderly individuals. Previous studies have suggested a link between elevated levels of total C‐reactive protein (CRP) in the choroid, CFH genotype, and AMD status; however, the structural form of CRP present in the choroid, its relationship ...
Chirco KR +7 more
europepmc +4 more sources
An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein. [PDF]
J Biol Chem, 2016 Most proinflammatory actions of C-reactive protein (CRP) are only expressed following dissociation of its native pentameric assembly into monomeric form (mCRP). However, little is known about what underlies the greatly enhanced activities of mCRP. Here we show that a single sequence motif, i.e. cholesterol binding sequence (CBS; a.a.
Li HY +11 more
europepmc +4 more sources
Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses. [PDF]
J Biol Chem, 2014 The activation of endothelial cells (ECs) by monomeric C-reactive protein (mCRP) has been implicated in contributing to atherogenesis. However, the potent proinflammatory actions of mCRP on ECs in vitro appear to be incompatible with the atheroprotective effects of mCRP in a mouse model.
Li HY +8 more
europepmc +4 more sources
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]
, 2015 A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV +7 more
core +4 more sources
C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights
Frontiers in Immunology, 2020 Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in ...
Peter C. Hart +3 more
doaj +1 more source
Role of C-Reactive Protein at Sites of Inflammation and Infection
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
doaj +1 more source
Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY +5 more
core +2 more sources
C-Reactive Protein in Atherothrombosis and Angiogenesis
Frontiers in Immunology, 2018 C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions.
Lina Badimon +10 more
doaj +1 more source
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]
, 2016 Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna +5 more
core +3 more sources
Monomeric C-Reactive Protein Decreases Acetylated LDL Uptake in Human Endothelial Cells [PDF]
Clinical Chemistry, 2009 AbstractBackground: C-reactive protein (CRP) is a risk marker for cardiovascular disease and has been implicated in atherogenesis. In atherosclerotic plaques, it colocalizes with oxidized LDL (oxLDL) and promotes oxLDL uptake by macrophages, suggesting an important cross-talk between CRP and lipid processing.
Susanne B, Schwedler +8 more
openaire +2 more sources