Results 101 to 110 of about 7,647 (170)

Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation

Advanced Science, Volume 12, Issue 38, October 13, 2025.
An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang, Juzheng Yuan, Niu Dai, Yanlin Ji, Wenguang Yang, Xiao Li, Siqi Yan, Jin Yan   +7 more
wiley   +1 more source

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines, 2020
The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD).
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Ekaterina Zubkova, Olga Guseva, Sergey Domogatsky, Tatiana Arefieva, Natalia Radyukhina, Maria Zvereva, Yuliya Avtaeva, Lyudmila Buryachkovskaya, Zufar Gabbasov   +11 more
doaj   +1 more source

Adaptive laboratory evolution of a genome-reduced Escherichia coli. [PDF]

, 2019
Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be ...
Cho, Byung-Kwan, Cho, Suhyung, Choe, Donghui, Hwang, Soonkyu, Kim, Sun Chang, Lee, Jun Hyoung, Palsson, Bernhard, Sung, Bong Hyun, Yoo, Minseob   +8 more
core   +2 more sources

C‐reactive protein‐to‐lymphocyte ratio as a prognostic biomarker for mortality in trauma: A retrospective study from a level I trauma center

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 5, October 2025.
Abstract Objective The C‐reactive protein‐to‐lymphocyte ratio (CLR) combines inflammatory and immune response markers, potentially providing valuable prognostic information for various illnesses. This study evaluated the efficacy of the CLR as a prognostic biomarker for predicting mortality in patients with trauma.
Ching‐Ya Huang, Pi‐Chieh Lin, Pao‐Jen Kuo, Shiun‐Yuan Hsu, Ching‐Hua Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Fcγ Receptors in Solid Organ Transplantation. [PDF]

, 2016
In the current era, one of the major factors limiting graft survival is chronic antibody-mediated rejection (ABMR), whilst patient survival is impacted by the effects of immunosuppression on susceptibility to infection, malignancy and atherosclerosis ...
A Coxon, A Loupy, A Loupy, A Loupy, A Lux, A Nicoletti, A Pawlik, A Pawlik, A Pincetic, A Regnault, A Suwanichkul, AB Magil, AM Boruchov, AM Kalergis, B Sis, C Ferrara, C Kishimoto, C Rosales, C Sur Chowdhury, CJ Callaghan, D Bharadwaj, D Kerjaschki, D Metes, DF Burut, DH Schuurhuis, DM Da Silva, E Mirre van, EC Jolly, F Nimmerjahn, F Nimmerjahn, FF Yuan, G Einecke, H Ait-Oufella, H Bian, H Ghesquieres, H Kono, HL Spiegelberg, HP Ng, I Gjertsson, JA Ericson, JA Kelly, JA Titus, JD Mellor, JM Venner, JN Arnold, K Kessenbrock, KGC Smith, KJ Tinckam, KM Dhodapkar, KM Dhodapkar, L Pricop, L Xu, LC Willcocks, LC Willcocks, LF Pan, LG Hidalgo, LG Hidalgo, LG Hidalgo, M Daeron, M Guilliams, M Haas, M Ono, M Zhao, MJ Zhou, ML Arnold, MR Clatworthy, MR Clatworthy, MR Clatworthy, MR Clatworthy, MR Clatworthy, N Ozkayin, NC Sundgren, NM Valenzuela, P Hernandez-Vargas, PA Kiener, PE Sharp, PJ Maglione, PT Diamantopoulos, PT Jindra, PT Jindra, R Clynes, RA Clynes, RJ Brownlie, RL Shields, S Albrecht, S Bournazos, S Devaraj, S Gavasso, S Shimizu, T Yuasa, TA Okabe, TN Mayadas, W Palinski, X Zhou, Y Liu, YV Mendez-Fernandez, Z Cui, Z Xiang, Z Yuan   +98 more
core   +2 more sources

Monomeric CRP and Negative Acute Phase Proteins but not pentameric CRP are biomarkers of major depression and especially major dysmood disorder

Abstract Background Contrary to the negative acute-phase protein (APP) response, there is no consistent correlation between serum pentameric C-reactive protein (pCRP) and major depression (MDD). Monomeric CRP (mCRP), a dissociation product of pCRP under immune-inflammatory conditions, exhibits pro-inflammatory
Almulla, Abbas F., Mengqi Niu, Drozdstoj Stoyanov, Yingqian Zhang, Maes, Michael   +4 more
openaire   +1 more source

Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR [PDF]

, 2017
The iron-sulfur cluster containing protein FNR is the master regulator for the switch between anaerobic and aerobic respiration in Escherichia coli and many other bacteria. The [4Fe-4S] cluster functions as the sensory module, undergoing reaction with O2
Crack, Jason C., Le Brun, Nick E., Thomson, Andrew J.   +2 more
core   +1 more source

C-reactive protein binds to alphaIIbbeta3. [PDF]

, 2008
C-reactive protein binds to ...
Brennan, Marian P, Chubb, Anthony J, Cox, Dermot, Grennan, S, Moriarty, Roisin D   +4 more
core  

Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury : a prospective cohort study of patients with sepsis [PDF]

, 2015
Background: The role of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for acute kidney injury (AKI) in sepsis is still debated.
Dhondt, Annemieke, Glorieux, Griet, Hoste, Eric, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +6 more
core   +2 more sources

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +1 more source