Results 111 to 120 of about 77,315 (282)

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

open access: yesiMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang   +9 more
wiley   +1 more source

Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish

open access: yesiMeta, EarlyView.
Evidence for liver metabolism of gut‐derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mannose supplementation under high‐fat diet conditions, convert arginine into putrescine.
Delong Meng   +10 more
wiley   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

open access: yesiMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang   +11 more
wiley   +1 more source

Techno‐economic analysis for hydroxy acids production from waste cellulose via alkaline digestion

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Alkaline digestion offers a promising route for converting low‐grade cellulosic wastes into valuable hydroxy carboxylic acids (HAs). However, the feasibility of producing HAs at process scale, particularly the influence of reactor design on product yields, energy demand, and production costs, remains less explored.
Farangis Fallahmehneh   +3 more
wiley   +1 more source

Electrospun encapsulation of grape pomace extract: in vitro antioxidant, anti‐inflammatory, and antihyperglycemic properties

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The escalating prevalence of lifestyle‐ and aged‐related conditions, including diabetes, chronic inflammation, and cardiovascular disorders, underscores the urgent need for natural therapies. Such alternatives should offer reduced side effects compared to conventional pharmaceuticals while playing a proactive role in disease ...
Estefani Tavares Jansen   +6 more
wiley   +1 more source

Cytocompatible Enzymatic Hydrogelation of Phenylboronic Acid‐Alginate via H2O2‐Triggered Deboronation

open access: yesMacromolecular Materials and Engineering, EarlyView.
This study develops a hydrogelation method for preparing hydrogels from precursors containing polymer‐PBA and HRP via H2O2‐triggered deboronation and subsequent enzymatic crosslinking. This hydrogelation method can impart dynamic properties to HRP‐mediated hydrogelation without any additives, thereby demonstrating the potential of this hydrogelation ...
Ryota Goto, Shinji Sakai
wiley   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

open access: yesMacromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh   +8 more
wiley   +1 more source

Influence of humic substances on results of the spectrophotometric (TPTZ) analysis of monosaccharides

open access: yesOceanologia, 2004
A spectrophotometric method of monosaccharide analysis was assessed with regard to its non-selectivity towards humic substances. Analysis of model solutions showed that it responds positively to both marine and terrestrial humics.
Waldemar Grzybowski   +1 more
doaj  

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