Synthesis of New Morphinan Opioids by TBADT-Catalyzed Photochemical Functionalization at the Carbon Skeleton. [PDF]
Chemistry, 2022 Gorbachev D +4 more
europepmc +3 more sources
Syntheses of Pentacyclic Morphinan Analogs [PDF]
Canadian Journal of Chemistry, 1975 The synthesis of a series of morphinans with an additional aromatic or alicyclic ring fused to the 5,6 positions or an alicyclic ring fused to the 16,17 positions is described. The synthetic sequence involved elaboration of a 1,2,3,4,5,6-hexahydrobenz[f]isoquinoline or a quinolizidine, Grewe cyclization to a morphinan, and modification of the ...
James L. Douglas, Jacques Meunier
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Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors [PDF]
, 2008 Muhammad Asim +3 more
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Molecules, 2023 The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in
Dana R. Chambers +5 more
doaj +1 more source
Preliminary Pharmacological Evaluation of Enantiomeric Morphinans
ACS Chemical Neuroscience, 2014 A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-D-aspartate (NMDA) channel, and sigma 1 and 2 receptors. It was found that levo isomers tended to have higher affinities at the opioid receptors and moderate to high affinities to the NMDA and ...
Anna W. Sromek +6 more
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Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]
, 2020 © The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa +3 more
core +2 more sources
The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime [PDF]
, 2013 The synthesis of 3-deoxyoripavine (7) was realized as a novel and promising intermediate towards the synthesis of the important class of dopaminergic and/or serotonergic 10- deoxyaporphines and the special pharmacological tool µ opioid antagonist ...
Berényi, Sándor +3 more
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Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor
British Journal of Pharmacology, Volume 180, Issue 18, Page 2341-2360, September 2023., 2023 Abstract Background and Purpose The illicit use of fentanyl‐like drugs (fentanyls), which are μ opioid receptor agonists, and the many overdose deaths that result, has become a major problem. Fentanyls are very potent in vivo, leading to respiratory depression and death.
Nokomis Ramos‐Gonzalez +7 more
wiley +1 more source
Molecules, 2018 The characterization of alkaloids is challenging because of the diversity of structures and the complicated fragmentation of collision induced structural dissociation in mass spectrometry.
Jinjun Shan +7 more
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Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity [PDF]
, 2014 Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain.
A Manglik +42 more
core +3 more sources