Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2015 Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoline ...
Elena Fossati +4 more
doaj +5 more sources
Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain [PDF]
Molecules, 2023 Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. However, the inadequate benefit/risk ratio of currently available opioids, together with the current ‘opioid crisis’, warrant ...
Helmut Schmidhammer +3 more
doaj +2 more sources
In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice [PDF]
Frontiers in Pharmacology, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Roberta Lattanzi +4 more
doaj +4 more sources
Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines [PDF]
Open Chemistry, 2013 Here we report on the transformation of tetracyclic morphinan salutaridine (1) into 2,3,10,11-tetrasubstituted (R)-aporphines. This method serves as another chemical proof of the previously verified biosynthetic connection with pentacyclic ...
Udvardy Antal, Sipos Attila
doaj +2 more sources
Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones [PDF]
Molecules, 2021 Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of ...
Mariana Spetea, Helmut Schmidhammer
doaj +2 more sources
A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids [PDF]
Advanced Science, Volume 13, Issue 1, 5 January 2026.A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu +8 more
wiley +2 more sources
Neuropsychopharmacological understanding for therapeutic application of morphinans [PDF]
Archives of Pharmacal Research, 2010 Morphinans are a class of compounds containing the basic structure of morphine. It is well-known that morphinans possess diverse pharmacological effects on the central nervous system. This review will demonstrate novel neuroprotective effects of several morphinans such as, dextromethorphan, its analogs and naloxone on the models of multiple ...
Eun‐Joo Shin +2 more
openalex +4 more sources
Electrospray tandem mass spectrometric investigations of morphinans [PDF]
Journal of the American Society for Mass Spectrometry, 2003 In this study positive ESI tandem mass spectra of the [M + H]+ ions of morphinan alkaloids obtained using an ion trap MS were compared with those from a triple quadrupole MS. This allows to assess the differences of the tandem-in-time versus the tandem-in-space principle, often hampering the development of ESI MS/MS libraries.
A. Cailleux +18 more
core +3 more sources
N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists. [PDF]
Sci Rep, 2020 Morphine and structurally-derived compounds are µ opioid receptor (µOR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential.
Dumitrascuta M +12 more
europepmc +5 more sources
Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway. [PDF]
Nat Commun, 2021 Yang X +11 more
europepmc +3 more sources