Results 11 to 20 of about 68 (63)
Antitumor activity of d-morphinan derivatives
Japanese Journal of Pharmacology, 1986 Sakae Iwagami +4 more
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Synthesis of Precursors of Novel Morphinan Analogues
Journal of Pharmacy and Pharmacology, 1990 L.A. Masterson +2 more
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Expeditious Access to Morphinans by Chemical Synthesis
Angewandte Chemie - International Edition, 2022AbstractMorphinans are essential medicines derived entirely from poppy supply chains rendered increasingly volatile by climate change. Here, we report a seven‐step, asymmetric chemical synthesis of (−)‐codeine from simple materials that requires a total combined reaction time of fewer than 24 hours.
Martin G Banwell
exaly +3 more sources
Syntheses of Pentacyclic Morphinan Analogs [PDF]
Canadian Journal of Chemistry, 1975 The synthesis of a series of morphinans with an additional aromatic or alicyclic ring fused to the 5,6 positions or an alicyclic ring fused to the 16,17 positions is described. The synthetic sequence involved elaboration of a 1,2,3,4,5,6-hexahydrobenz[f]isoquinoline or a quinolizidine, Grewe cyclization to a morphinan, and modification of the ...
Jacques Meunier, James L. Douglas
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Anticonvulsant effects of new morphinan derivatives [PDF]
Bioorganic & Medicinal Chemistry Letters, 2001 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Eun-Joo Shin +7 more
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ChemInform Abstract: Enantioselective Approach to Morphinans.
ChemInform, 1990Abstract Enantioselective synthesis of morphinan derivative 20 from 2,7-dimethoxynaphthalene has been achieved in twelve steps (11% overall yield).
Gilbert Revial +3 more
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Hydroxy‐morphinane. 12. Mitteilung. Die Konfiguration der Morphinane
Helvetica Chimica Acta, 1959AbstractIt has been shown that synthetic (–)‐3‐hydroxy‐N‐methyl‐morphinane (I) possesses the same steric configuration at the C‐atoms 9, 13 and 14 as the natural mor‐phine alkaloids, since it can be degraded to the known (–)‐cis‐ [2‐methyl‐carboxy‐cyclohexyl‐(l)]‐acetic‐acid.
E. Hardegger +9 more
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Chemistry and biology of ent-morphinan alkaloids
2023Morphinan alkaloids have attracted constant attention since the isolation of morphine by Sertürner in 1805. However, a group of 45 compounds possessing a complete ent-morphinan backbone can also be found in the literature. These compounds are related to the morphinandienone subgroup and display a substitution pattern which is different from the ...
Keita, A., /Duval, Romain, Porée, F.H.
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Synthesis of aminothiazole derived morphinans
Tetrahedron Letters, 2003Two aminothiazole derived morphinans 9 and 11 were prepared for our ongoing opioid ligands study. The synthesis was initiated from levorphanol 1, which was first triflated, and then subjected to Pd-catalyzed reduction followed by nitration. The resulting two nitrated isomers were characterized by analogy to known compounds.
Sander van Vliet +2 more
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Oxy‐morphinane. (3. Mitteilung). Optisch aktive 3‐Oxy‐morphinane
Helvetica Chimica Acta, 1951Abstract3‐Oxy‐N‐alkyl‐morphinane wurden in die optischen Antipoden gespalten und diese in Äther und Ester übergeführt.
O. Schnider, A. Grüssner
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