Results 101 to 110 of about 55,011 (233)

Repeated Tetrahydrocannabinol Injections Induce Tolerance but Do Not Disrupt Ongoing Behaviour Upon Withdrawal in Male and Female Rats With Inflammatory Pain

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Background Many people use cannabis to self‐medicate for pain. Little is known about the impact of pain on tolerance and spontaneous withdrawal to delta‐9‐tetrahydrocannabinal (THC), the primary psychoactive compound in cannabis. Our previous research with the opioid morphine suggests persistent pain will increase the magnitude and duration of
Michael M. Morgan, Christa M. Hickey
wiley   +1 more source

The Effect of Nicotine Administration on Physical and Psychological Signs of Withdrawal Syndrome Induced by Single or Frequent Doses of Morphine in Rats

Basic and Clinical Neuroscience, 2012
Introduction. Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and ...
Mohammad Allahtavakoli, Fatemeh Amin, Elham Hakimizadeh, Ali Roohbakhsh, Sayed Ali Haeri Rohani, Ahmad Taghavi Rafsanjani, Abbas Haghparast, Ali Shamsizadeh   +7 more
doaj   +2 more sources

Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry [PDF]

, 2017
The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the
Moore, Amanda Marie
core  

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

The Effect of Nitric Oxide Microinjection in Nucleus Accumbens Shell on Morphine Withdrawal Signs in Male Rats [PDF]

Journal of Kerman University of Medical Sciences, 2005
Introduction: This study was performed to evaluate the effects of intra-nucleus accumbens shell microinjection of Larginine (NO precursor) and L-NAME (nitric oxide synthase (NOS) inhibitor) on morphine withdrawal signs in male rats.
V Sheibani, Gh Sepehri, F Baghaiee, R Farazifard   +3 more
doaj  

A Background of the Opioid Epidemic and Its Relationship to the Medicaid Expansion [PDF]

, 2019
Despite the recent increase in public awareness of the opioid epidemic, the background of this epidemic is still disappointingly unknown to the public.
Jang, Er Yearn
core   +2 more sources

Adverse Effects Associated With Spinal Versus General Anaesthesia for Hip and Knee Arthroplasties: Protocol for a Systematic Review

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 5, May 2026.
ABSTRACT Background Spinal and general anaesthesia are the most common anaesthetic methods for hip and knee arthroplasties. Differences in their effects on short‐ and long‐term postoperative outcomes, including mortality morbidity, and adverse events, remain uncertain.
Anne Sofie Nautrup Therkelsen, Hans Bredgaard Christensen, Anne‐Lene Kjældgaard, Camilla Godthaab, Christina Dam Bjerregaard Sillassen, Troels Haxholdt Lunn, Daniel Hägi‐Pedersen, Claus Varnum, Martin Lindberg‐Larsen, Kasper Højgaard Thybo, Janus Christian Jakobsen, Ole Mathiesen   +11 more
wiley   +1 more source

Addiction‐related problems in Japan: A regional perspective

Addiction, Volume 121, Issue 5, Page 1316-1324, May 2026.
Abstract Japan's addiction landscape appears paradoxical. The lifetime use of illicit drugs is among the lowest in Organisation for Economic Cooperation and Development countries, but harm from alcohol, tobacco, and gambling ranks among the world's highest.
Soichiro Ide, Yoko Nishitani, Masahiko Sumitani, Masabumi Minami, Tadashi Isa, Masako Iseki, Michiko Ohkura, Hitoshi Okamoto, Tetsuro Kikuchi, Yuko Sekino, Hidehiko Takahashi, Kenji Takeuchi, Atsumi Nitta, Takeshi Honjo, Hiroshi Matsumoto, Tsuyoshi Miyakawa, Toshiya Murai, Toshihiko Matsumoto, Kazuyuki Nakagome, Kazutaka Ikeda   +19 more
wiley   +1 more source

Heroin withdrawal as a possible cause of acute concomitant esotropia in adults [PDF]

, 2001
Aim: To report the possible effects of heroin withdrawal on binocular vision. Methods: To present a case series of patients in whom esotropia developed on cessation of heroin use.
Firth, A.Y.
core