Results 101 to 110 of about 226,399 (222)

The effects of adding ketamine to morphine in patient-controlled intravenous analgesia after orthopedic surgeries [PDF]

Aim and Background: A routine method to control post-operative pain is patient-controlled intravenous analgesia (PCIA) using opioids. Regarding complications of opioids, it seems necessary to reduce their dosage and to improve the quality of analgesia ...
ایمانی, فرناد, محمدیان اردی, علی, اخوان اکبری, قدرت   +2 more
core  

Protracted opioid withdrawal behaviors are reduced by nitric oxide inhibition in mice

Addiction Neuroscience
Following opioid cessation, patients with opioid use disorder experience physical and psychological withdrawal symptoms. Prolonged negative affect, including anxiety and heightened stress reactivity, continues after physical withdrawal symptoms subside ...
Daniel J Kalamarides, Aditi Singh, John A Dani   +2 more
doaj   +1 more source

The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Introduction 37%–48% of older patients receive anticholinergic medicines, increasing the risk for falls, delirium, dementia and death. Hospital admission may provide an opportunity for deprescribing to improve outcomes. This study evaluated the feasibility and acceptability of a digital tool to identify anticholinergic medicines and support ...
Kinda Ibrahim, Eloise Radcliffe, Edward Hewertson, Andrew Bates, Andy Fox, Emily Smith, Cathrine Mckenzie, Liam Jones, Sara Mckelvie, Ngianga Ii Kandala, Sara McCloskey, Tracey Sach, Stephen Lim   +12 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model. [PDF]

Int J Mol Sci, 2023
Jones GC, Small CA, Otteson DZ, Hafen CW, Breinholt JT, Flora PD, Burris MD, Sant DW, Ruchti TR, Yorgason JT, Steffensen SC, Bills KB.   +11 more
europepmc   +1 more source

Non‐Prescribed Gabapentinoid Use: Demographic and Behavioural Risk Profiles in a Large International Sample

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction The harm potential of gabapentinoids is well established, with concerns about non‐medical use increasing alongside prescribing rates. However, less is known about the characteristics of people who use gabapentinoids obtained through non‐prescribed routes.
Jennifer Seddon, Monica J. Barratt, Cheneal Puljević, Jason A. Ferris, Adam R. Winstock, Emma L. Davies   +5 more
wiley   +1 more source

Morphine Withdrawal-Induced Hyperalgesia in Models of Acute and Extended Withdrawal Is Attenuated by l-Tetrahydropalmatine. [PDF]

Int J Mol Sci, 2023
Oleinichenko D, Ahn S, Song R, Snutch TP, Phillips AG.   +4 more
europepmc   +1 more source

Fentanyl Detection in Biological Samples From Individuals Reporting Synthetic Cannabinoid Use in São Paulo, Brazil

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction Brazil has historically exhibited low illicit opioid prevalence, though forensic data indicate rising fentanyl seizures, often in combination with other substances. People who use Synthetic cannabinoid receptor agonists (SCRA) are particularly vulnerable to unintentional fentanyl exposure due to the unpredictable chemical ...
Ligia Goes Endo, Rodrigo Alves de Oliveira, Ivan Dieb Miziara, Mauricio Yonamine, João Maurício Castaldelli‐Maia, Vilma Leyton, Henrique Silva Bombana   +6 more
wiley   +1 more source

Application of Morphine Anesthesia for Oral Surgery [PDF]

, 2004
P(論文)Morphine anesthesia is often applied for the cardiovascular surgery and to patients complicated with cardiovascular disease because it has a property of hemodynamic stability due to the block from nociceptive stimulation and pain. However, there are
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Factors Associated With Postsurgical Pain in Children and Adolescents With Cognitive Dysfunction

Journal of Clinical Nursing, Volume 35, Issue 9, Page 3794-3804, September 2026.
ABSTRACT Aim To describe the characteristics of paediatric postoperative patients with cognitive dysfunction and assess the prevalence of pain and associated factors. Desing A descriptive observational study. Methods Cross‐sectional study in children and adolescents who had undergone surgery in the previous 72 h with cognitive dysfunction impeding ...
Débora Sierra‐Núñez, Alejandro Bosch‐Alcaraz, Sandra Parada‐Almansa, Mónica Castro‐Fernández, Susana Asensio‐Sales, Daniel Gracia‐Martínez, Anna Falcó‐Pegueroles, Mª. Ángeles Saz‐Roy, Esperanza Zuriguel‐Pérez   +8 more
wiley   +1 more source