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Rare Presentation of Intrathecal Morphine Withdrawal Psychosis
Pain Management, 2017We report a case of a 57-year-old male patient with intrathecal morphine pump failure who presented with psychosis as part of a clinical presentation of opioid withdrawal. The patient was being treated for chronic back pain with an intrathecal morphine pump for several years.
Rohit, Aiyer +4 more
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Morphine suppression of ethanol withdrawal in mice
Experientia, 1976The acute administration of morphine, alcohol or dopamine results in a pronounced suppression of the convulsions produced by alcohol in mice. The suppressive action of morphine on alcohol withdrawal in the mouse apparently is not a product of morphine intoxication, but rather to some other specific interaction between alcohol and morphine in the ...
K, Blum +3 more
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Modification of morphine withdrawal by interferon
Life Sciences, 1983Abstract Naloxone was administered to morphine dependent rats to elicit the opioid abstinence syndrome. Recombinant leukocyte A interferon treatment one hour prior to naloxone injection eliminated almost all of the abstinence behavioral signs observed.
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Conditioned morphine withdrawal in the hamster
Psychopharmacology, 1992Conditioned withdrawal among golden Syrian hamsters was studied in two experiments. In experiment 1, morphine-pelleted (75 mg) hamsters were observed for signs of withdrawal (wet-dog shakes, etc.) before and after a naloxone (1 mg/kg) injection that was administered in a distinctive environment.
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Increased shock induced aggression during morphine withdrawal
Life Sciences, 1971Abstract Spontaneous fighting and footshock-induced aggression of male Wistar rats were recorded before and during morphine administration to produce dependence, and after withdrawal. The morphine dependent rats showed spontaneous fighting on the 3rd through 5th days of withdrawal.
W M, Davis, J H, Khalsa
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Immediate early gene expression during morphine withdrawal
Neuropharmacology, 1995The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-precipitated morphine withdrawal in various organs of the rat. Dependence was induced over a period of 6 days by a graded regimen of 6-hourly injections.
Beckmann A.M., Matsumoto I., Wilce P.A.
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Clonidine in Morphine Withdrawal
Archives of General Psychiatry, 1985Reports of an antiwithdrawal effect for clonidine hydrochloride in acute opioid withdrawal are inconsonant with experimental findings that other nonopioids are ineffective. In the present investigation the antiwithdrawal effects of clonidine, morphine sulfate, and placebo were compared in volunteer addicts whose dependence was maintained by 15 mg of ...
D R, Jasinski, R E, Johnson, T R, Kocher
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Morphine withdrawal-facilitated aggression is attenuated by morphine-conditioned stimuli
Pharmacology Biochemistry and Behavior, 2001There is a considerable body of evidence indicating that stimuli associated with drug administration may become conditioned and evoke drug-like effects. The purpose of this study was to evaluate the ability of morphine-paired stimuli to affect an expression of morphine withdrawal-facilitated aggression.
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Morphine withdrawal response and central cholinergic activity
Nature, 1975MOST of the different neurotransmitter systems have been implicated in opiate withdrawal. Frederickson and Pinsky1 suggested a primary role for acetylcholine (ACh) in both the development and the expression of dependence on morphine but the specific role of cholinergic mechanisms in opiate withdrawal is not yet clear and deserves further attention. The
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