Results 81 to 90 of about 25,416 (201)

Protracted opioid withdrawal behaviors are reduced by nitric oxide inhibition in mice

Addiction Neuroscience
Following opioid cessation, patients with opioid use disorder experience physical and psychological withdrawal symptoms. Prolonged negative affect, including anxiety and heightened stress reactivity, continues after physical withdrawal symptoms subside ...
Daniel J Kalamarides, Aditi Singh, John A Dani   +2 more
doaj   +1 more source

The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal

Addiction Biology, Volume 31, Issue 3, March 2026.
Buprenorphine can either precipitate or relieve opioid withdrawal depending on the timing of administration relative to full opioid agonist exposure. The article proposes that buprenorphine promotes mu‐opioid receptor (MOR) externalization and resensitization, creating a temporary signaling gap that explains precipitated withdrawal when full agonists ...
Mehdi Haghdoost, Jennifer LaBranche, Matthew Roberts, Victor W. Li, Jane J. Kim, James S. H. Wong, Pouya Azar   +6 more
wiley   +1 more source

Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits

Addiction Biology, Volume 31, Issue 3, March 2026.
Polysubstance opioid–stimulant use is increasingly prevalent, yet its behavioral consequences remain poorly understood. We compared single versus combined fentanyl and methamphetamine exposure in male and female rats, assessing locomotor sensitization and sociability during withdrawal.
Leah M. Salinsky, Kyra C. Diaz, Joshua L. Fox, Shawn M. Panh, Susan M. Ferguson   +4 more
wiley   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

Factors Associated With Opioid Agonist Treatment Engagement and Harm Reduction Service Use: Findings From the New South Wales Opioid Dependence Survey

Drug and Alcohol Review, Volume 45, Issue 3, March 2026.
ABSTRACT Introduction Opioid agonist treatment (OAT) is one of the most effective treatments for opioid dependence, but there can be barriers to accessing treatment. This study examined characteristics associated with OAT engagement—never, previous or current—among people with opioid dependence in NSW, Australia, following recent reforms to OAT access.
Thomas Santo Jr, Chrianna Bharat, Craig Rodgers, Mary Harrod, Sophia Taylor, Emma Zahra, Rachel Sutherland, Amy Peacock, Jason Grebely, Matthew Hickman, Michael Farrell, Louisa Degenhardt   +11 more
wiley   +1 more source

Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model. [PDF]

Int J Mol Sci, 2023
Jones GC, Small CA, Otteson DZ, Hafen CW, Breinholt JT, Flora PD, Burris MD, Sant DW, Ruchti TR, Yorgason JT, Steffensen SC, Bills KB.   +11 more
europepmc   +1 more source

Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Memories of rewarding experiences powerfully shape behavior, yet when maladaptive, they can drive psychiatric conditions including addiction, depression, and PTSD. Memory traces, or engrams, have been extensively studied for fear memories in the hippocampal dentate gyrus.
Lorianna M. Colón, Oluwatoni A. Famuyide, Amelia J. Eisch   +2 more
wiley   +1 more source

The Effect of Ethanol Extract of Aerial Parts of the Mentha piperita in the Acquisition, Tolerance Expression and Dependence to Morphine in Adult Male Mice

Armaghane Danesh Bimonthly Journal, 2015
Background & aim: Morphine dependence is a compulsive pattern of drug taking, resulting from the positive reinforcement of the rewarding effects of drug taking and the negative reinforcement of withdrawal syndrome that accompanies the cessation of drug ...
N Khajeh, A Eidi, J Zarringhalam
doaj  

Morphine Withdrawal-Induced Hyperalgesia in Models of Acute and Extended Withdrawal Is Attenuated by l-Tetrahydropalmatine. [PDF]

Int J Mol Sci, 2023
Oleinichenko D, Ahn S, Song R, Snutch TP, Phillips AG.   +4 more
europepmc   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source