Results 61 to 70 of about 31,100 (249)

Design, synthesis, in silico studies and antiproliferative evaluation of some novel hybrids of pyrimidine-morpholine

open access: yesFrontiers in Chemistry
IntroductionCancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. These cells can invade nearby tissues and organs, or they may metastasize to other parts of the body through the ...
Elaheh Ataollahi   +10 more
doaj   +1 more source

(Morpholin-4-yl)[2-(morpholin-4-yl)-3,5-dinitrophenyl]methanone

open access: yesActa Crystallographica Section E, 2012
In the title compound, C15H18N4O7, the morpholine rings adopt chair conformations. The benzene ring forms dihedral angles of 55.94 (7) and 63.19 (7)° with the planes through the C atoms of the two morpholine rings.
Chao Gao   +3 more
doaj   +1 more source

Chronic morpholine exposure of rats

open access: yesFundamental and Applied Toxicology, 1989
The chronic toxicity and carcinogenic potential of morpholine were evaluated in 60 Sprague-Dawley rats/sex/group receiving morpholine at mean inhalation exposure concentrations of 0, 10, 50 and 150 ppm for 6 hr/day, 5 days/week, for 104 weeks. Survival, body weight gains, organ weights, hematology, and clinical chemistries were normal in exposed groups
Center for Environmental Toxicology, University of Florida, Alachua, Florida 32615 USA ( host institution )   +5 more
openaire   +3 more sources

Extending Peptide Ligation to Acidic pH and Junctions Comprising Glycosylated and Phosphorylated Amino Acids

open access: yesAngewandte Chemie International Edition, EarlyView.
A pyridine‐containing ligation auxiliary eliminates a major bottleneck of peptide ligation chemistry. The extended range of applicable pH values (2.0–7.5) in the ligation reaction helps to avoid epimerization. Native chemical ligation (NCL) proceeds at virtually any junction, including reactions at β‐branched amino acids, as well as O‐glycosylated or O‐
Sebastian Trunschke   +5 more
wiley   +1 more source

2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin

open access: yesPharmaceuticals, 2010
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization.
Floris L. van Delft   +5 more
doaj   +1 more source

Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines

open access: yesMolbank, 2021
The ammonium salts of many drugs have significantly improved the solubility and, accordingly, the bioavailability of medicinal substances in the human body.
Yuliya E. Ryzhkova   +2 more
doaj   +1 more source

Morpholines-(I)

open access: yesZeitschrift für Naturforschung B, 1970
ω- (N-aryl-chloracetamido) -acetophenones have been cyclized with triethylamine in warm benzene solution to the corresponding 1,4-oxazines. The reaction appears to be general for any N-aryl substituent, as long as an overall electron-withdrawing substituent is present para- or meta, in the aromatic nucleus of the acetophenone moiety.
Basanta G. Chatterjee, Riaz F. Abdulla
openaire   +1 more source

Departing from standard practices: Strategic application of value engineering in the anatomy laboratory to enhance formaldehyde extraction using high‐impact, low‐cost, and low‐maintenance solutions

open access: yesAnatomical Sciences Education, Volume 18, Issue 3, Page 241-253, March 2025.
Abstract This study describes the process of developing a high‐impact, low‐cost, and low‐maintenance air ventilation system for anatomy facilities. It employed the strategic application of Value Engineering (VE), assuring that the air ventilation system meets contemporary threshold limit values (TLVs) for formaldehyde in the working zone of dissection ...
Jürgen Russ, Niels Hammer
wiley   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon   +3 more
wiley   +1 more source

Coherence in nonradiative transitions: internal conversion in Rydberg-excited N-methyl and N-ethyl morpholine

open access: yes, 2017
The survival of coherent wavepacket motion during internal conversions is observed in relatively large molecules,N-methyl morpholine andN-ethyl morpholine, where standard models imply fast decoherence in a statistical limit.
Yao Zhang   +2 more
core   +1 more source

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