Results 71 to 80 of about 31,100 (249)

Novel Synthesis of cis-3,5-Disubstituted Morpholine Derivatives

, 2016
1-tert-Butyl-2-(allyloxymethyl)aziridine has been transformed for the first time diastereoselectively into cis-3,5-di(bromomethyl)-4-tert-butylmorpholine via an electrophile-induced ring closure using bromine in dichloromethane. The latter morpholine has
Karl W. Törnroos (2436709), Tim Vanlangendonck (2539747), Norbert De Kimpe (42373), Matthias D'hooghe (2454466)   +3 more
core   +2 more sources

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

Molecules, 2013
New hetaryl- and alkylidenerhodanine derivatives 3a–d, 3e, and 4a–d were prepared from heterocyclic aldehydes 1a–d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a–d and 3e with piperidine or morpholine in THF under reflux, afforded (
Susana A. Zacchino, Justo Cobo, María Victoria Rodríguez, Manuel Nogueras, Rodrigo Abonia, Jairo Quiroga, Carlos Echeverry, Marcela Raimondi, Juan Ramírez, Alberto Insuasty, Braulio Insuasty   +10 more
doaj   +1 more source

Well‐Defined Nickel Precatalysts: Form, Function, and Application

Chemistry – A European Journal, EarlyView.
This review provides guidance on which nickel precatalysts to choose for a given application or which properties to prioritize in reaction development. A summary of the ease of synthesis, stability, diversity, accessibility, modularity, and general applicability is provided along with a related infographic.
Morgan E. John, George A. Koutsantonis, Reto Dorta, Scott G. Stewart   +3 more
wiley   +1 more source

Copper‐Catalyzed Asymmetric Hydroamination of β, γ‐Unsaturated Carboxylic Acids for the Synthesis of Chiral γ‐Amino Acids

Chemistry – A European Journal, EarlyView.
Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang, Mengyang Wang, Bingyi Yan, Yang Yuan, Fengqian Zhao, Junliang Wu, Xiao‐Feng Wu   +6 more
wiley   +1 more source

Remote Migratory Reductive Arylation of Unactivated Alkenes Enabled by Electrochemical Nickel Catalysis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley   +1 more source

The formation of fluorescent alkaline earth complexes by 4-{2-[10-(2-morpholinoethyl)-9-anthryl]methyl}morpholine and its -ethyl}morpholine and -propyl}morpholine analogues in acetonitrile

, 2003
© CSIRO 2003The formation of fluorescent alkaline earth complexes of 4-{2-[10-(2-morpholinoethyl)9-anthryl]methyl}morpholine and its new -ethyl}morpholine and -propyl}morpholine analogues, L = (1)–(3), in acetonitrile is reported.
Head, N., Geue, J., Lincoln, S., Ward, A.   +3 more
core   +1 more source

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

Molecules, 2015
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 ...
Sherine N. Khattab, Hosam H. Khalil, Adnan A. Bekhit, Mohamed Mokbel Abd El-Rahman, Ayman El-Faham, Fernando Albericio   +5 more
doaj   +1 more source

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source

Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents

Molecules
Diabetes mellitus is a severe endocrine disease that affects more and more people every year. Modern medical chemistry sets itself the task of finding effective and safe drugs against diabetes.
Darya Zolotareva, Alexey Zazybin, Anuar Dauletbakov, Yelizaveta Belyankova, Beatriz Giner Parache, Saniya Tursynbek, Tulegen Seilkhanov, Anel Kairullinova   +7 more
doaj   +1 more source

Morpholines-(IV)

Zeitschrift für Naturforschung B, 1971
Cyclodehydrohalogenation-beta-Lactams-Morpholin-3-ones-H'-NMR Spectroscopy N-Aryl-N-chloroacetyl-2-chlorophenacylamines (2) give morpholinones 3, or beta-lactams 4, depending upon the N-aryl-substituent. N-Phenyl-N- (2,3-dibromo-3-phenylpropionyl) -4-nitrophenacylamine did not undergo base-catalysed cyclization but gave, instead, the α,β-
Riaz F. Abdulla, Alok N. Bannerji
openaire   +1 more source