Results 81 to 90 of about 45,031 (289)

Selective β-oxidation of α-sulfanyl amides [PDF]

, 2011
A selective β-oxidation of a series of α-sulfanyl amides to the corresponding β-oxo-α-sulfanyl amides is described. This selective efficient oxidation of an unfunctionalised methyl or methylene group occurs under mild conditions, involving three ...
Bateman, Lorraine M., Kissane, Marie, Maguire, Anita R., McCarthy, Daniel G., Murphy, Maureen   +4 more
core   +1 more source

Electrochemically Driven Domino Nucleophilic Addition/Diels–Alder Reaction: From 2‐Aminophenol Derivatives to Bridged Tricyclic Systems

European Journal of Organic Chemistry, EarlyView.
This electrochemical methodology allows the preparation of bridged tricyclic scaffolds through a rapid increase in the molecular complexity of simple and readily accessible starting materials. Alcohols proved to be the most efficient nucleophiles, as well as 6‐chloropurine. Plausibly, the process involves an anodic oxidative dearomatization to generate
Emanuele Cartamina, Sara Colombo, Davide Spanu, Gianluigi Broggini, Camilla Loro   +4 more
wiley   +1 more source

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

Molecules, 2015
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 ...
Sherine N. Khattab, Hosam H. Khalil, Adnan A. Bekhit, Mohamed Mokbel Abd El-Rahman, Ayman El-Faham, Fernando Albericio   +5 more
doaj   +1 more source

Morpholines — (II)

Zeitschrift für Naturforschung B, 1970
The new route to the synthesis of 3-oxo-1,4-oxazines 1 has been extended. N-aryl-N-chloroacetyl-m-nitro-phenacyl amines afford either only oxazine, or beta-lactam or both depending on the nature of the N-aryl substituent. A set of rules indicates from which precursors beta-lactam, as against morpholine formation, may be expected.
Basanta G. Chatterjee, S. K. Lahiri, Riaz F. Abdulla   +2 more
openaire   +1 more source

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra, Ruzal Sitdikov, Hasil Aman, Alyssio Calis, Gergely Laczkó, Virgile Rouffeteau, Maxime R. Vitale, Imre Pápai, Oscar Verho   +8 more
wiley   +2 more sources

Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents

Molecules
Diabetes mellitus is a severe endocrine disease that affects more and more people every year. Modern medical chemistry sets itself the task of finding effective and safe drugs against diabetes.
Darya Zolotareva, Alexey Zazybin, Anuar Dauletbakov, Yelizaveta Belyankova, Beatriz Giner Parache, Saniya Tursynbek, Tulegen Seilkhanov, Anel Kairullinova   +7 more
doaj   +1 more source

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]

, 2009
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates, A. F Hurlstone, A. F Moorman, A. G Passerini, A. M Malek, A. R Brooks, A. S Forouhar, Arian S. Forouhar, B. C Groenendijk, B. C Groenendijk, C Ethier, C Hahn, C. H Kim, D Beis, D. J Milan, David Wu, Diane Plummer, E Berdougo, E. C Walsh, E. J Armstrong, G Bendig, G Garcia-Cardena, G. B Atkins, G. P Sorescu, H Kokubo, H. J Auman, Hiroshi Hamada, J Alexander, J Pan, J. L Galloway, J. N Chen, J. R Hove, J. S Lee, Julien Vermot, K. M Parmar, L. A Timmerman, M Liebling, M Xin, M Yamada, Michael Liebling, Morteza Gharib, N Sultana, N. C Chi, N. C Chi, P. J Scherz, R. D Kortschak, R. J Dekker, R. J Dekker, S Isogai, S Quintin, S. M McCormick, S. M Meadows, S. W Jin, Scott E. Fraser, T Bartman, T Bartman, T Lecuit, T Lecuit, T. R Cummins, X. L Wang, Y Fung   +60 more
core   +5 more sources

Preparation of 4,7‐Dihalobenzo[b]Thiophene Derivatives Containing Iodine Atoms and Their Cross Coupling With Arylethynes

Journal of Heterocyclic Chemistry, EarlyView.
Quasi T‐shaped three‐way benzo[b]thiophene scaffolds, containing iodine atom(s) at the 4‐ and/or 7‐position, were prepared by several methods such as silica gel‐assisted cyclization. The iodobenzo[b]thiophenes thus prepared were subjected to Sonogashira cross couplings to give various ethynylbenzo[b]thiophenes.
Kozo Toyota, Hiroki Kishi, Keita Nakayama, Tatsuya Inaba, Taisei Hanagasaki, Kento Miwa, Tomoyuki Ito, Hiyori Igarashi, Yuki Igarashi, Shinichi Mikami   +9 more
wiley   +1 more source

Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
Combining unsymmetrical sulfurdiimide reagents (R‐NSN‐R1) and Grignard reagents, followed by oxidative amination, delivers a series of vinyl sulfondiimidamides. Reactivity with cysteine and lysine derivatives is shown, and the cysteine reactivity is mapped in detail. Variation of the two imidic N‐substituents can be used to tune reactivity of these new
Katherine G. Rodden, Agamemnon E. Crumpton, Samuel E. Dalton, Michael A. Clegg, Michael C. Willis   +4 more
wiley   +2 more sources