Results 81 to 90 of about 24,393 (218)

Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis

Frontiers in Chemistry
An important component of the pathogenicity of potentially pathogenic bacteria in humans is the urease enzyme. In order to avoid the detrimental impact of ureolytic bacterial infections, the inhibition of urease enzyme appears to be an appealing approach.
Rubina Munir, Sumera Zaib, Muhammad Zia-ur-Rehman, Hira Javed, Ayesha Roohi, Muhammad Zaheer, Nabiha Fatima, Mashooq Ahmad Bhat, Imtiaz Khan   +8 more
doaj   +1 more source

Remote Migratory Reductive Arylation of Unactivated Alkenes Enabled by Electrochemical Nickel Catalysis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley   +1 more source

Synthesis and properties of morpholino-substituted 2H-imidazole N-oxides as potential endothelioprotectors

Chimica Techno Acta
5-Morpholino-substituted 2H-imidazole 1-oxides have recently proven themselves as perspective molecules to counteract the pathological states associated with endothelial dysfunction.
Alexey A. Akulov, Anna A. Nelyubina, Ilya I. Butorin, Vsevolod V. Melekhin, Maria D. Tokhtueva, Mikhail V. Korokin, Mikhail V. Pokrovskii, Mikhail V. Varaksin, Oleg N. Chupakhin   +8 more
doaj   +1 more source

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source

Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis

European Journal of Organic Chemistry, EarlyView.
The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall, Sam Tucker, Max J. Cryle, Julien Tailhades   +3 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of N-(2,6-dimethylphenyl)-2-morpholinoacetamide, a Lidocaine analog

Acta Crystallographica Section E: Crystallographic Communications
In the title molecule, C14H20N2O2, the dihedral angle between the mean plane of the phenyl ring and that defined by the ipso-C—NH—(C= O)—CH2— unit is 66.59 (11)°. The morpholine unit adopts a chair conformation. In the crystal, N—H...O hydrogen bonds and
Imane Maimoune, Abderrazzak El Moutaouakil Ala Allah, Benson M. Kariuki, Abdulsalam Alsubari, Joel T. Mague, Abdelkader Zarrouk, Youssef Ramli   +6 more
doaj   +1 more source

Stereoselective and Diastereospecific Aminosilylation and Hydrosilylation of Heterobicyclic Alkenes by Copper Catalysis Under Mild Conditions

European Journal of Organic Chemistry, EarlyView.
An efficient and straightforward methodology for the stereoselective and diastereospecific aminosilylation and hydrosilylation of heterobicyclic norbornene derivatives is introduced. The mild conditions enable the functionalization of norbornene substrates with broad functional‐group tolerance.
Daniel Kamzol, Wende Chen, Aleksander Hoffman, René Wilhelm   +3 more
wiley   +1 more source

Lead‐free halide perovskites for efficient light‐emitting devices

FlexMat, EarlyView.
Overview of Lead‐free metal halide perovskites with different categories and optoelectronic application directions, including solid‐state lighting, light‐emitting diodes, piezoluminescence, flexible electronics, scintillators and CPL emitters. Abstract Lead halide perovskites exhibit promising optoelectronic properties for optoelectronic applications ...
Yueqi Shen, Kefan Meng, Yiqi Zhao, Chaoran Zhou, Jiaye Shu, Di Zhang, Chengqian Cao, Wanxin Chen, Yefeng Zhou, Weihua Ning   +9 more
wiley   +1 more source

Chain‐End Grafting of RAFT Polyelectrolyte Macroligands to Stabilize Near‐Infrared‐Emitting Gold Nanoclusters

Macromolecular Rapid Communications, EarlyView.
Surface‐functionalized gold nanoclusters (AuNCs) are synthesized in situ by chain‐end grafting of RAFT polyelectrolytes at room temperature directly in water. It leads to highly stable polymer‐AuNCs nanohybrids emitting near‐infrared photoluminescence with µs lifetimes. ABSTRACT With their photoluminescence properties, gold nanoclusters (AuNCs, d<2 nm)
Bárbara Casteleiro, Pierre Alcouffe, Fernande Da Cruz, Agnès Crépet, José Manuel Gaspar Martinho, Marie‐Thérèse Charreyre, José Paulo Sequeira Farinha, Arnaud Favier   +7 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source