Pain Fluctuations in Parkinson’s Disease and Their Association with Motor and Non-Motor Fluctuations [PDF]
Journal of Parkinson’s DiseaseBackground: Pain fluctuations are a characteristic phenomenon in advanced Parkinson’s disease (PD), but their temporal association with motor and non-motor symptom (NMS) fluctuations remains largely enigmatic.
Alexander Storch +5 more
doaj +4 more sources
Frequency of Non-motor Symptoms in Parkinson's Patients With Motor Fluctuations [PDF]
Frontiers in Neurology, 2021 Background: Non-motor symptoms (NMS), including neuropsychiatric, sleep, autonomic, and sensory domains, are an integral aspect of the clinical presentation of Parkinson disease (PD) and affect neurocognitive functioning as well as patients' and ...
Mariana Fernandes +12 more
doaj +7 more sources
Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease [PDF]
Frontiers in Neurology, 2023 IntroductionLong-term levodopa treatment in patients with Parkinson’s disease (PwPD) often causes motor fluctuations, which are known to affect their quality of life (QOL). These motor fluctuations may be accompanied by fluctuations in non-motor symptoms.
Asako Kakimoto +5 more
doaj +2 more sources
Hallucinations and parkinsonian Motor Fluctuations [PDF]
Behavioural Neurology, 1992 Thirty patients with Parkinson's disease experiencing hallucinations during long-term treatment were compared with 20 parkinsonian patients without hallucinations. No differences were found in the duration of disease, L-dopa treatment or disease severity
W. Fernandez, G. Stern, A. J. Lees
doaj +3 more sources
Real-world data of opicapone in patients with Parkinson’s disease experiencing motor fluctuations: the OPTIMO study [PDF]
Frontiers in NeurologyPurposeEvaluate the outcomes of opicapone as an add-on treatment to levodopa/DDCI in patients with Parkinson’s disease (PD) and motor fluctuations (MF) in a real-world setting.MethodsObservational, retrospective, and post-authorization study in patients ...
María‑Rosario Luquin +18 more
doaj +2 more sources
Brownian motors: current fluctuations and rectification efficiency [PDF]
Physical Review E, 2004 With this work we investigate an often neglected aspect of Brownian motor transport: The r\^{o}le of fluctuations of the noise-induced current and its consequences for the efficiency of rectifying noise. In doing so, we consider a Brownian inertial motor
F. Marchesoni +8 more
core +5 more sources
Intestinal Decontamination Therapy for Dyskinesia and Motor Fluctuations in Parkinson's Disease [PDF]
Frontiers in Neurology, 2021 Parkinson's disease is neurodegenerative disorder with an initial robust response to levodopa. As the disease progresses, patients frequently develop dyskinesia and motor fluctuations, which are sometimes resistant to pharmacological therapy.
José Fidel Baizabal-Carvallo +2 more
doaj +2 more sources
Early start of opicapone in Parkinson’s disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations [PDF]
Frontiers in NeurologyBackgroundLevodopa is the mainstay of Parkinson’s disease (PD) therapy, but its long-term use is often complicated by the development of motor fluctuations.
Joaquim J. Ferreira +17 more
doaj +2 more sources
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study [PDF]
Diagnostics, 2022 Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF).
Diego Santos-García +50 more
doaj +2 more sources
Motor fluctuations in Parkinson’s disease: Perceptions and treatment
Dialogues in Clinical Neuroscience & Mental Health, 2023 Background: Levodopa is the gold standard of treatment for Parkinson’s disease, but wearing off leads to motor fluctuations in most patients. Therapeutic strategy for motor fluctuation management relies heavily on physician judgement; however, real-world
Fabrizio Stocchi +2 more
doaj +1 more source