Nonlinearity of mechanochemical motions in motor proteins. [PDF]
PLoS Computational Biology, 2010 The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics.
Yuichi Togashi +2 more
doaj +9 more sources
Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators [PDF]
eLife, 2017 The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway
Jutta Nesper +9 more
doaj +3 more sources
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
Micron-scale geometrical features of microtubules as regulators of microtubule organization
eLife, 2021 The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Tunnelling nanotubes (TNTs) are membranous connections that represent a unique type of intercellular communication in different cell types. They are associated with cell physiology and cancer pathology.
Nataša Resnik +7 more
doaj +1 more source
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]
, 2020 In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana +36 more
core +1 more source
Mechanisms of Regulation in Intraflagellar Transport
Cells, 2022 Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia act as antennae to sense a cell’s environment and are involved in a wide range of signaling pathways essential for development. Motile cilia drive cell locomotion
Wouter Mul +2 more
doaj +1 more source
Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era
BMC Evolutionary Biology, 2017 Background The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several intracellular ...
Martin Kollmar, Stefanie Mühlhausen
doaj +1 more source
Length control of microtubules by depolymerizing motor proteins [PDF]
, 2008 In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the ...
B. S. Govindan +3 more
core +2 more sources
Coupling of Two Motor Proteins: a New Motor Can Move Faster [PDF]
, 2005 We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is presented.
Anatoly B. Kolomeisky +8 more
core +1 more source