Results 21 to 30 of about 498,521 (337)
Connecting two arrays: The emerging role of actin-microtubule cross-linking motor proteins
Frontiers in Plant Science, 2015 The cytoskeleton of plant cells, consisting of actin filaments (AFs) and microtubules (MTs), is a central structure for various intracellular processes, such as cell division, isotropic and polar growth, vesicle transport, cell shape and morphogenesis ...
René eSchneider, Staffan ePersson
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The landscape of human mutually exclusive splicing
Molecular Systems Biology, 2017 Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification with pivotal roles in organismal development and diseases such as Timothy syndrome, cardiomyopathy and cancer in humans.
Klas Hatje +10 more
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Cortical proteins may provide motor resilience in older adults
Scientific Reports, 2021 Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman +11 more
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Single molecule thermodynamics of ATP synthesis by F1-ATPase
New Journal of Physics, 2015 F _o F _1 -ATP synthase is a factory for synthesizing ATP in virtually all cells. Its core machinery is the subcomplex F _1 -motor (F _1 -ATPase) and performs the reversible mechanochemical coupling.
Shoichi Toyabe, Eiro Muneyuki
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Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
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Symmetry Breaking and Emergence of Directional Flows in Minimal Actomyosin Cortices
Cells, 2020 Cortical actomyosin flows, among other mechanisms, scale up spontaneous symmetry breaking and thus play pivotal roles in cell differentiation, division, and motility.
Sven K. Vogel +5 more
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Motor Proteins: Myosin Mechanosensors [PDF]
Current Biology, 2008 Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
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Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment
Frontiers in Cellular Neuroscience, 2017 The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport,
Anne F. J. Janssen +5 more
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Dendritic trafficking faces physiologically critical speed-precision tradeoffs
eLife, 2016 Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model
Alex H Williams +3 more
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