Results 101 to 110 of about 819,058 (310)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sensor-Based Quantification of MDS-UPDRS III Subitems in Parkinson’s Disease Using Machine Learning

Sensors
Wearable sensors could be beneficial for the continuous quantification of upper limb motor symptoms in people with Parkinson’s disease (PD). This work evaluates the use of two inertial measurement units combined with supervised machine learning models to
Rene Peter Bremm, Lukas Pavelka, Maria Moscardo Garcia, Laurent Mombaerts, Rejko Krüger, Frank Hertel   +5 more
doaj   +1 more source

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]

, 2018
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S, Cutler, Tamara, Howland, David, Loh, Dawn H, Wang, Huei-Bin, Whittaker, Daniel S   +5 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Motor coordination problems in children and adolescents with ADHD rated by parents and teachers: effects of age and gender [PDF]

, 2007
Summary. Objective. ADHD is frequently accompanied by motor coordination problems. However, the co-occurrence of poor motor performance has received less attention in research than other coexisting problems in ADHD.
A Cummins, AS Niemeijer, B Kadesjo, B Kadesjo, B. Franke, BL Van der Waerden, BN Wilson, C Gillberg, C Gillberg, C Gillberg, C Gillberg, C. J. M. Buschgens, D Dewey, D Sugden, DM Hall, E Taylor, E. Fliers, FX Castellanos, HJ Polatajko, J Biederman, J Biederman, J Biederman, J Cairney, J Gibbs, J Kuntsi, J Visser, J. A. Sergeant, J. K. Buitelaar, JA Sergeant, JM Swanson, JP Piek, K Brookes, LC Magalhaes, LJ Seidman, M Hadders-Algra, M Miyahara, M Miyahara, M. Altink, MD Rappley, MH Cantell, MH Tseng, MM Schoemaker, MM Schoemaker, MM Schoemaker, N. Rommelse, NC Martin, P Rasmussen, P Shaw, PH Wilson, R Goodman, RA Skinner, RH Geuze, S. H. H. M. Vermeulen, S. V. Faraone, SG Crawford, SK Berument, T Archer, T Banaschewski, T Banaschewski, T Dellen van, TM Pitcher, V Roessner   +61 more
core   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Frontiers in Neurology
Available data suggest that there may be gender differences in the effect of STN-DBS in the treatment of Parkinson’s disease (PD). The aim of this study was to review data on gender discrepancies and gender differences in clinical outcomes in PD patients
Martijn Hendriks, Martijn Hendriks, Ruben Saman Vinke, Dejan Georgiev, Dejan Georgiev   +4 more
doaj   +1 more source

Neurobiology of dyslexia : A reinterpretation of the data [PDF]

, 2004
Theories of developmental dyslexia differ on how to best interpret the great variety of symptoms (linguistic, sensory, motor) observed in dyslexic individuals. One approach views dyslexia as a specific phonological deficit, which sometimes co-occurs with
Ramus, Franck
core   +4 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source