Results 81 to 90 of about 819,058 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prevalence and impact of rapid eye movement sleep behavior disorder in multiple system atrophy: a systematic review and meta-analysis

Frontiers in Neurology
ObjectiveMultiple system atrophy (MSA) is commonly associated with rapid eye movement sleep behavior disorder (RBD). Research on the prevalence of RBD in MSA and its effects on MSA patients has yielded inconsistent results.
Hui Wang, Ting Zhang, Wenhui Fan
doaj   +1 more source

Non-Dopaminergic Drugs for Motor Symptoms

, 2012
A new optimism that Parkinson's disease can be defeated is energizing the research community. Halting the progression of the disease, restoring function, and even prevention are all realistic goals. This comprehensive volume provides state-of-the-art information on all aspects of Parkinson's disease, including epidemiology, genetics, diagnosis ...
Burkhard, Pierre, Vingerhoets, François
openaire   +2 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The role of Tai Chi in managing Parkinson's disease: A review of therapeutic mechanisms and clinical outcomes

Journal of Education, Health and Sport
Tai Chi is a traditional Chinese martial art characterized by maintaining postures and performing slow, fluid movements. This exercise involves actions like extending the knees and hips, shifting weight, flexing, rotating the trunk, and coordinating arm
Adrianna Marta Paziewska, Karolina Jurasz, Radosław Cymer, Ewa Rzeska, Michał Rogulski   +4 more
doaj   +1 more source

Epilepsy – A Brief Overview [PDF]

, 2005
Epilepsy is a neurological condition in which an individual experiences chronic abnormal bursts of electrical discharge in the brain. These seizures can cause a variety symptoms depending on the areas of the brain affected. Symptoms can vary from mild to
Koyama, Alain
core  

Automated operant assessments of Huntington's Disease mouse models [PDF]

, 2018
Huntington’s disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to ...
A Burns, A Lunkes, AD Lawrence, AD Lawrence, AE Horner, AJ Mitchell, AJ Morton, B Baldo, B Skinner, C Clelland, C Kipps, CF Jacobsen, CL Julien, D Craufurd, D Helder, D Yang, DC Rogers, E Dowd, E Dowd, E Mayer, E Yhnell, E Yhnell, E Yhnell, F Yue, J Paulsen, J Snowden, J Talpos, J-C Bensadoun, JC Jacobsen, JC Thompson, JF Gusella, JM Raamsdonk Van, JN Crawley, JR Slaughter, JS Paulsen, K Kubota, L Mangiarini, L Menalled, M Carli, M Carli, M D’amato, MD Döbrössy, MD Döbrössy, ME MacDonald, P Thompson, PC Curtin, PJ Brasted, PW Faber, R Diamond, RC Josiassen, RC Trueman, RC Trueman, RC Trueman, RC Trueman, RC Trueman, RE Ready, S Baudic, S Brooks, S Brooks, S Hörsten von, S Kirkwood, S Klöppel, S-H Yang, SA Johnson, SB Dunnett, SB Dunnett, SB Dunnett, SB Dunnett, SB Dunnett, SJ Tabrizi, SJ Tabrizi, SJ Tabrizi, SM McTighe, SP Brooks, SP Brooks, SP Brooks, T Humby, T Robbins, T-B Robins Wahlin, V Tucci, W Duan, WD Spaulding   +81 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Subregional 6-[18F]fluoro-ʟ-m-tyrosine Uptake in the Striatum in Parkinson's Disease [PDF]

, 2011
Background In idiopathic Parkinson's disease (PD) the clinical features are heterogeneous and include different predominant symptoms. The aim of the present study was to determine the relationship between subregional aromatic l-amino acid decarboxylase ...
Sayaka Asari, Ken-ichi Fujimoto, Akihiro Miyauchi, Toshihiko Sato, Imaharu Nakano, Shin-ichi Muramatsu   +5 more
core   +1 more source