Global Down-regulation of Gene Expression Induced by Mouse Mammary Tumor Virus (MMTV) in Normal Mammary Epithelial Cells [PDF]
Viruses, 2023 Mouse mammary tumor virus (MMTV) is a betaretrovirus that causes breast cancer in mice. The mouse mammary epithelial cells are the most permissive cells for MMTV, expressing the highest levels of virus upon infection and being the ones later transformed ...
Waqar Ahmad +7 more
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The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV) [PDF]
Viruses, 2022 A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a species jump from mice to humans.
Generoso Bevilacqua
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Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue [PDF]
Viruses, 2022 Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi +4 more
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Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Mouse mammary tumor virus (MMTV) is a virus that induces breast cancer in mice. During lactation, MMTV can transmit from mother to offspring through milk, and Peyer’s patches (PPs) in mouse intestine are the first and specific target organ.
Lankai Chen +6 more
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Association of Mouse Mammary Tumor Virus With Human Breast Cancer: Histology, Immunohistochemistry and Polymerase Chain Reaction Analyses [PDF]
Frontiers in Oncology, 2018 PurposeThe purpose of this study is to determine whether mouse mammary tumor virus (MMTV)-associated human breast cancer has the same or similar histology to MMTV-associated mouse mammary tumors.
James S. Lawson +9 more
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Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10−/− mouse model of inflammatory bowel disease [PDF]
Microbiome, 2023 Background Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain-specific fashion that serves as a model for inflammatory bowel disease (IBD).
Heather Armstrong +12 more
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Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China [PDF]
Infectious Agents and Cancer, 2021 Background Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear.
Fa-liang Wang +8 more
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Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus [PDF]
Journal of Inflammation Research, 2022 Jianwen Ren, Xiaoying Ning, Dingwei Zhang, Yanfei Zhang Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xian, Shaanxi Province, People’s Republic of ChinaCorrespondence: Yanfei ZhangDepartment of Dermatology, The ...
Ren J, Ning X, Zhang D, Zhang Y
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Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]
Biomolecules & BiomedicineDecitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson +9 more
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Pericentriolar Targeting of the Mouse Mammary Tumor Virus GAG Protein. [PDF]
PLoS ONE, 2015 The Gag protein of the mouse mammary tumor virus (MMTV) is the chief determinant of subcellular targeting. Electron microscopy studies show that MMTV Gag forms capsids within the cytoplasm and assembles as immature particles with MMTV RNA and the Y box ...
Guangzhi Zhang +7 more
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