Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]
Biomolecules & BiomedicineDecitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson +9 more
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Pericentriolar Targeting of the Mouse Mammary Tumor Virus GAG Protein. [PDF]
PLoS ONE, 2015 The Gag protein of the mouse mammary tumor virus (MMTV) is the chief determinant of subcellular targeting. Electron microscopy studies show that MMTV Gag forms capsids within the cytoplasm and assembles as immature particles with MMTV RNA and the Y box ...
Guangzhi Zhang +7 more
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Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia [PDF]
BMC Cancer, 2018 Background Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in several studies from different ...
Reem Al Dossary +2 more
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Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [PDF]
BMC BiologyBackground Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells.
Lisbeth Berrueta +11 more
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Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine [PDF]
Frontiers in ImmunologyIntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye +6 more
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IFI16/IFI202 blockade suppresses tumor growth through CD8+ T-cell–mediated immunity [PDF]
Breast Cancer ResearchBackground Tumor-associated macrophages (TAMs) are key drivers of immunosuppressive inflammation in the breast cancer microenvironment, promoting tumor progression and resistance to immune checkpoint blockade.
Ga Young Lim +3 more
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Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice
Current Issues in Molecular Biology, 2023 Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and
Chien-Liang Liu +6 more
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Special Issue “Human Betaretrovirus and Related Diseases”
Viruses, 2022 A betaretrovirus resembling mouse mammary tumor virus (MMTV) was first linked with human breast cancer over 50 years ago [...]
Andrew L. Mason
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Merlin deficiency alters the redox management program in breast cancer
Molecular Oncology, 2021 The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota +6 more
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Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source