Results 11 to 20 of about 96,662 (219)

Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis [PDF]

Viruses, 2010
Mouse mammary tumor virus (MMTV), which was discovered as a milk‑transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer.
Susan R. Ross
doaj   +3 more sources

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia [PDF]

BMC Cancer, 2018
Background Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in several studies from different ...
Reem Al Dossary, Khaled R. Alkharsah, Haitham Kussaibi   +2 more
doaj   +2 more sources

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine [PDF]

Frontiers in Immunology
IntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye, Ivan Petrov, Ivaylo Gentschev, Eman M. Othman, Aladar A. Szalay, Aladar A. Szalay, Aladar A. Szalay   +6 more
doaj   +2 more sources

IFI16/IFI202 blockade suppresses tumor growth through CD8+ T-cell–mediated immunity [PDF]

Breast Cancer Research
Background Tumor-associated macrophages (TAMs) are key drivers of immunosuppressive inflammation in the breast cancer microenvironment, promoting tumor progression and resistance to immune checkpoint blockade.
Ga Young Lim, Na-Lee Ka, Seung-Su Kim, Mi-Ock Lee   +3 more
doaj   +2 more sources

Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice

Current Issues in Molecular Biology, 2023
Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and
Chien-Liang Liu, Wen-Chien Huang, Shih-Ping Cheng, Ming-Jen Chen, Chi-Hsin Lin, Shao-Chiang Chang, Yuan-Ching Chang   +6 more
doaj   +1 more source

Special Issue “Human Betaretrovirus and Related Diseases”

Viruses, 2022
A betaretrovirus resembling mouse mammary tumor virus (MMTV) was first linked with human breast cancer over 50 years ago [...]
Andrew L. Mason
doaj   +1 more source

Merlin deficiency alters the redox management program in breast cancer

Molecular Oncology, 2021
The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota, Brandon J. Metge, Dominique C. Hinshaw, Heba A. Alsheikh, Dongquan Chen, Rajeev S. Samant, Lalita A. Shevde   +6 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Cryoelectron Microscopy of Mouse Mammary Tumor Virus [PDF]

Journal of Virology, 2004
ABSTRACT Cryoelectron microscopy of Mouse mammary tumor virus , a Betaretrovirus , provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses.
Briggs, J., Watson, B., Gowen, B., Fuller, S.   +3 more
openaire   +3 more sources

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +6 more sources