Results 151 to 160 of about 39,988 (211)
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Neuropathology, 2001
After the discovery of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), we acquired a good animal model of Parkinson's disease. The extraordinary recent growth in knowledge using MPTP parkinsonism has fostered increased understanding of Parkinson's disease.
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After the discovery of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), we acquired a good animal model of Parkinson's disease. The extraordinary recent growth in knowledge using MPTP parkinsonism has fostered increased understanding of Parkinson's disease.
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Movement Disorders, 2008
Rhesus and vervet monkeys respond differently to treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride neurotoxin (MPTP). Both species develop akinesia, rigidity, and severe postural instability. However, rhesus monkeys only develop infrequent, short episodes of high-frequency tremor, whereas vervet monkeys have many prolonged ...
H, Bergman +7 more
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Rhesus and vervet monkeys respond differently to treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride neurotoxin (MPTP). Both species develop akinesia, rigidity, and severe postural instability. However, rhesus monkeys only develop infrequent, short episodes of high-frequency tremor, whereas vervet monkeys have many prolonged ...
H, Bergman +7 more
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Effects of MPTP on the cerebrovasculature
International Journal of Developmental Neuroscience, 1991AbstractThe neurotoxin, l‐methyl‐4‐phenyl‐l,2,3,6‐tetrahydropyridine, has been shown to cause pooling of blood in the brain microvasculature and decrease the permeability of the blood‐brain barrier. All areas of the brain examined in this study were affected.
J D, Adams +3 more
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MPTP and convulsive responses in rodents
Brain Research, 1987Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg/kg s.c. for 5 days) to mice resulted in complete abolishment of strychnine seizure and of the tonic phase of the maximal electroshock response. Bicuculline and picrotoxin convulsions were not significantly affected by MPTP treatment.
R G, Fariello +4 more
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Tremor in MPTP‐induced parkinsonism
Neurology, 1992We assessed clinical and electrophysiologic characteristics of tremor in patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Four of seven patients with moderate to severe MPTP-induced parkinsonism exhibited a tremor indistinguishable from the characteristic rest tremor of Parkinson's disease (PD).
J W, Tetrud, J W, Langston
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The MPTP model of Parkinson's disease
Molecular Brain Research, 2005The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations.
Richard Jay, Smeyne +1 more
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The hypothalamus in MPTP-induced parkinsonism
The Italian Journal of Neurological Sciences, 19901-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) has been shown to produce a parkinsonian syndrome in humans and other primates. Recent studies have demonstrated that in humans the hypothalamus has the highest binding density for (3H) MPTP, which corresponds to monoamine oxidase type B (MAO-B).
R, Sandyk, R P, Iacono, S R, Kay
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Suspected MPTP-induced parkinsonism
Journal of Clinical Neuroscience, 1997The case of an intravenous heroin user who developed parkinsonian symptoms from the age of 28 years is presented. Neuropathologic examination revealed a marked loss of neurons and gliosis with the presence of Lewy bodies in the substantia nigra and locus ceruleus; they stained variably with antibody to ubiquitin and negatively with antibodies to tau ...
K, Opeskin, R M, Anderson
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2014
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxicant that damages the nigrostriatal system and causes a parkinsonian motor syndrome in humans and experimental animal models. It is a classic protoxin because its fully oxidized 1-methyl-4-phenylpyridinium metabolite is actually responsible for neurotoxicity. Neuronal damage results from
Di Monte, Donato Antonio, Jewell, S. A.
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxicant that damages the nigrostriatal system and causes a parkinsonian motor syndrome in humans and experimental animal models. It is a classic protoxin because its fully oxidized 1-methyl-4-phenylpyridinium metabolite is actually responsible for neurotoxicity. Neuronal damage results from
Di Monte, Donato Antonio, Jewell, S. A.
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In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity
Neurochemistry International, 1985The compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a parkinsonian syndrome in humans and primates. We have previously found that metabolism of MPTP to a quaternary species is necessary for the expression of its neurotoxic effects.
J N, Johannessen +4 more
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