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IV. MPTP, MPP+ and mitochondrial function
Life Sciences, 19871-Methyl-4-phenylpyridinium (MPP+), the putative toxic metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), inhibited NAD(H)-linked mitochondrial oxidation at the level of Complex I of the electron transport system. MPTP and MPP+ inhibited aerobic glycolysis in mouse striatal slices, as measured by increased lactate ...
W J, Nicklas +3 more
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2000
Abstract The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine (MPTP) was identified in 1983 as the contaminant of synthetic illicit drugs that caused the abrupt onset of parkinsonian signs in young drug addicts (27). MPTP is commercially available as a hydrochloride salt.
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Abstract The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine (MPTP) was identified in 1983 as the contaminant of synthetic illicit drugs that caused the abrupt onset of parkinsonian signs in young drug addicts (27). MPTP is commercially available as a hydrochloride salt.
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MPTP ? Motivation, Implementation, First Experiments
Journal of Automated Reasoning, 2004zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Trends in Neurosciences, 1985
Abstract Recognition of the biological effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound which is selectively toxic to the zona compacta of substantia nigra, has stimulated a renaissance of basic research in Parkinson's disease.
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Abstract Recognition of the biological effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound which is selectively toxic to the zona compacta of substantia nigra, has stimulated a renaissance of basic research in Parkinson's disease.
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Bioenergetic Approaches and Inflammation of MPTP Toxicity
2005Abstract : We wish to continue to examine a number of new neuroprotective agents ill the MPTP model of PD, which act by inhibiting the mitochondrial permeability transition (MPT) We also wish to utilize metabolomic profiling to identify novel biomarkers for PD and to investigate whether these occur ill animal models of PD.
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1988
The last five years have witnessed a remarkable outpouring of scientific literature on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or MPTP, a newly described parkinsonogenic neurotoxin. Perhaps the only thing that has surpassed this meteoric rise has been the speed with which concepts regarding its mechanism of action have left the realm of active ...
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The last five years have witnessed a remarkable outpouring of scientific literature on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or MPTP, a newly described parkinsonogenic neurotoxin. Perhaps the only thing that has surpassed this meteoric rise has been the speed with which concepts regarding its mechanism of action have left the realm of active ...
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