Results 61 to 70 of about 4,135 (173)

Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening

Biotechnology Journal, Volume 21, Issue 8, August 2026.
Graphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Taeho Yu, Woo Dae Jang, Sang Yup Lee
wiley   +1 more source

Virtual Screening of Bacteriocins From Lactic Acid Bacteria Against Monkeypox DNA Polymerase: Sakacin P and Mundticin KS Emerge as Promising Candidates

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study employs an in silico virtual screening workflow to evaluate lactic acid bacteria (LAB)‐derived bacteriocins as potential inhibitors of the monkeypox virus DNA polymerase (MPDP). Protein‐peptide docking simulations using the HADDOCK platform revealed that Sakacin P and Mundticin KS possess the highest binding affinities for the MPDP target ...
Melisa Z. Karaman, Karan Goel, Fernando Berton Zanchi, Aykut Ozdarendeli, Somdutt Mujwar, Ahmet E. Yetiman, Ozkan Fidan   +6 more
wiley   +1 more source

Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts

Vaccines
Objectives: Understanding the antibody response in monkeypox virus (MPXV)-infected and uninfected individuals is essential for developing next-generation MPXV vaccines.
Nannan Jia, Lin Ai, Yunping Ma, Chen Hua, Qi Shen, Chen Wang, Teng Li, Yingdan Wang, Yunyi Li, Yin Yang, Chi Zhou, Min Chen, Huanyu Wu, Xin Chen, Lu Lu, Yanqiu Zhou, Jinghe Huang, Fan Wu   +17 more
doaj   +1 more source

Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus

Microorganisms
The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it.
Zhong-Hao Lian, Chen-Hui Yang, Ye Qiu, Xing-Yi Ge   +3 more
doaj   +1 more source

Diagnostic approaches for monkeypox virus

iLABMED
Mpox (formerly Monkeypox) is a zoonotic infection caused by Monkeypox virus (MPXV). Since 2022, Mpox epidemics have occurred in many non‐endemic countries and regions, leading the World Health Organization to declare a public health emergency of ...
Guohao Fan, Jiahua Kuang, Shengjie Zhang, Yang Yang, Yingxia Liu, Hongzhou Lu   +5 more
doaj   +1 more source

Urine metabolomic analyses reveal metabolite disruptions in steroid hormone biosynthesis in monkeypox

iScience
Summary: Monkeypox virus (MPXV) poses a global health threat. Viral infection can alter host metabolic homeostasis, while its changes may influence disease severity and progression. The relationship between MPXV and metabolites has not been reported.
Xiaofeng Yang, Huiqin Yang, Chudan Liang, Fei Tang, Zhenyu Long, Linjin Fan, Yulong Wang, Zequn Wang, Mou Zeng, Weifang Kang, Pengfei Ye, Wendi Shi, Yuandong Zhou, Jingyan Lin, Hongxin Huang, Huijun Yan, Jian Wang, Linghua Li, Jun Qian, Linna Liu   +19 more
doaj   +1 more source

Exploring the genomic basis of Mpox virus-host transmission and pathogenesis

mSphere
Mpox disease, caused by the monkeypox virus (MPXV), was recently classified as a public health emergency of international concern due to its high lethality and pandemic potential.
Brayden Young, Stephanie N. Seifert, Crystal Lawson, Heather Koehler   +3 more
doaj   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science
The global outbreak of mpox caused by the mpox virus (MPXV) in 2022 and 2024 underscores the urgent need to elucidate mechanisms governing viral replication during pathogenesis. Metabolic reprogramming is a conserved hallmark of viral infections, however,
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
doaj   +1 more source

Genomic variability and immunological aspects involved in response to MPXV infection

Frontiers in Pharmacology
Mpox, caused by the monkeypox virus (MPXV), is a zoonotic disease that has gained global relevance after the 2022–2024 outbreak. MPXV exists in two distinct clades: clade I, associated with higher virulence and mortality, and clade II, which demonstrated increased human-to-human transmission and adaptation.
La Frazia, Simone, Garbuglia, Anna Rosa, Pauciullo, Silvia, Zulian, Verdiana, Del Porto, Paola   +4 more
openaire   +2 more sources