Results 61 to 70 of about 5,325 (169)

Urine metabolomic analyses reveal metabolite disruptions in steroid hormone biosynthesis in monkeypox

iScience
Summary: Monkeypox virus (MPXV) poses a global health threat. Viral infection can alter host metabolic homeostasis, while its changes may influence disease severity and progression. The relationship between MPXV and metabolites has not been reported.
Xiaofeng Yang, Huiqin Yang, Chudan Liang, Fei Tang, Zhenyu Long, Linjin Fan, Yulong Wang, Zequn Wang, Mou Zeng, Weifang Kang, Pengfei Ye, Wendi Shi, Yuandong Zhou, Jingyan Lin, Hongxin Huang, Huijun Yan, Jian Wang, Linghua Li, Jun Qian, Linna Liu   +19 more
doaj   +1 more source

Nano‐Silver‐Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Exploration, Volume 6, Issue 3, June 2026.
There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang, Mengjun Li, Zining Liu, Jiayin Chen, Ke Liu, Fengfang Wei, Junrui Li, Yixuan Xie, Yushan Jiang, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Minghui Yang, Hua Ma, Ruilin Zhang, Chenguang Shen, Yuhui Liao   +15 more
wiley   +1 more source

Serologic analysis of mice infected with MPXV.

, 2013
BALB/c and C57BL/6 mice were challenged with either Congo Basin MPXV (CB) or West African MPXV (WA) by either an intranasal (IN) or foot pad (FP) route of infection (n = 5 in each group).
Jorge E. Osorio (211899), Jason A. Abel (367591), Darin S. Carroll (193931), Christine M. Hughes (193951), Kevin L. Karem (193972), Inger K. Damon (190329), Christina L. Hutson (193929), Zachary H. Braden (367594), Michael Dillon (367595), Consuelo Hopkins (367596), Victoria A. Olson (193962)   +10 more
core   +1 more source

MPXV infection impairs IFN response but is partially sensitive to IFN-γ antiviral effect

The recent outbreak of monkeypox virus (MPXV) has caused global concern. How the virus evades the interferon (IFN) response is still poorly understood.
Viscidi R. P., Mazzetti P., Scagnolari C., Bordi L., Maggi F., Fracella M., Antonelli G., D'Auria A., Mazzotta V., d'Ettorre G., Antinori A., Lalle E., Frasca F., Pistello M.   +13 more
core   +2 more sources

Exploring the genomic basis of Mpox virus-host transmission and pathogenesis

mSphere
Mpox disease, caused by the monkeypox virus (MPXV), was recently classified as a public health emergency of international concern due to its high lethality and pandemic potential.
Brayden Young, Stephanie N. Seifert, Crystal Lawson, Heather Koehler   +3 more
doaj   +1 more source

A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Muslim Bin Aqeel, Asif Hanif, Shahzad Ahmad, Fatima Iftikhar Shah, Benish Javed, Shazia Iqbal   +5 more
wiley   +1 more source

Directing Defense: ZBP1 Activation during MPXV Infection 2309240

Introduction Monkeypox virus (MPXV) remains a global health concern due to the recent outbreak that exhibited an increase in human transmission.
Anoli Karunathilake, Reem Miah, Heather Koehler   +2 more
core   +1 more source

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science
The global outbreak of mpox caused by the mpox virus (MPXV) in 2022 and 2024 underscores the urgent need to elucidate mechanisms governing viral replication during pathogenesis. Metabolic reprogramming is a conserved hallmark of viral infections, however,
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
doaj   +1 more source

Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling

iScience
Summary: Mpox virus (MPXV) infection exhibits different case fatality rates and symptoms depending on its clade. However, there has been insufficient molecular biological analysis of the differences between clades.
Yoshitaka Nakata, Masako Yamasaki, Yukio Watanabe, Keiya Uriu, Rina Hashimoto, Takuya Yamamoto, Kei Sato, Akatsuki Saito, Kazuo Takayama   +8 more
doaj   +1 more source